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Hdc Gene Detail
Summary
  • Symbol
    Hdc
  • Name
    histidine decarboxylase
  • Synonyms
    Hdc-a, Hdc-c, Hdc-e, Hdc-s, L-histidine decarboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96062
    NCBI Gene: 15186
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126435587-126461219 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband E5-G
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    646 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96062
 protein coding gene Chr2:126435579-126465942 (-)
129S1/SvImJ ENSMUSG00200045695
 protein coding gene Chr2:123495477-123520478 (-)
A/J ENSMUSG00195029390
 protein coding gene Chr2:123515906-123540908 (-)
AKR/J ENSMUSG00220044054
 protein coding gene Chr2:123281698-123306703 (-)
BALB/cJ ENSMUSG00180046479
 protein coding gene Chr2:123302843-123327854 (-)
C3H/HeJ ENSMUSG00175038237
 protein coding gene Chr2:123845089-123870028 (-)
C57BL/6NJ ENSMUSG00215017858
 protein coding gene Chr2:123356843-123381861 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024239
 protein coding gene Chr2:119285078-119305954 (-)
CAST/EiJ ENSTCUG00005033370
 protein coding gene Chr2:122647047-122672031 (-)
CBA/J ENSMUSG00210031150
 protein coding gene Chr2:123693558-123718504 (-)
DBA/2J ENSMUSG00185029652
 protein coding gene Chr2:123347578-123372512 (-)
FVB/NJ ENSMUSG00205024734
 protein coding gene Chr2:122518496-122543496 (-)
JF1/MsJ ENSUMUG00000008316
 protein coding gene Chr2:123199418-123224363 (-)
LP/J ENSMUSG00230035264
 protein coding gene Chr2:125130931-125155934 (-)
NOD/ShiLtJ ENSMUSG00190013833
 protein coding gene Chr2:123488719-123513721 (-)
NZO/HlLtJ ENSMUSG00225026529
 protein coding gene Chr2:133037073-133062071 (-)
PWK/PhJ ENSLUMG00010037773
 protein coding gene Chr2:123095099-123120203 (-)
SPRET/EiJ ENSMSPG00010029196
 protein coding gene Chr2:125524225-125551617 (-)
WSB/EiJ ENSIUOG00005037529
 protein coding gene Chr2:123290609-123315653 (-)



Homology
more
  • Human Ortholog
    HDC, histidine decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDC, histidine decarboxylase
  • Links
    NCBI Gene ID: 3067
    UniProt: P19113

  • Chr Location
    15q21.2; chr15:50241947-50265965 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hdc mouse models; 3 with human HDC associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    155 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mast cells, altered anxiety-related and nociceptive behavior, altered cognitive function, increased weight gain, visceral adiposity, increased amount of brown adipose tissue, impaired glucose tolerance, hyperinsulinemia, and hyperleptinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    239
  • cDNA Data
    56
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027360 Ensembl Gene Model | MGI Sequence Detail 25633 C57BL/6J ±  kb
    transcript ENSMUST00000028838 Ensembl | MGI Sequence Detail 2392 Not Applicable  
    polypeptide ENSMUSP00000028838 Ensembl | MGI Sequence Detail 662 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008489 histidine decarboxylase
      (term hierarchy)
    • EC
      4.1.1.22
    • InterPro Domains
      IPR010977 Aromatic-L-amino-acid decarboxylase
      IPR021115 Pyridoxal-phosphate binding site
      IPR002129 Pyridoxal phosphate-dependent decarboxylase, major domain
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 60
      Primer pair 4
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10682, MGD-MRK-10683, MGD-MRK-10684, MGD-MRK-10685, MGD-MRK-10686, MGI:2139302, MGI:96063, MGI:96064, MGI:96065, MGI:96066
    References
    more
    • Summaries
      All 254
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 11
      Phenotypes 155
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387502 Morishita Y, et al., Infraslow histaminergic dynamics govern priming states to gate moment-to-moment memory accessibility. Neuron. 2026 Jun 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory