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Serpind1 Gene Detail
Summary
  • Symbol
    Serpind1
  • Name
    serine (or cysteine) peptidase inhibitor, clade D, member 1
  • Synonyms
    Hcf2, HCII, HC II, heparin cofactor II
  • Feature Type
    protein coding gene
  • IDs
    MGI:96051
    NCBI Gene: 15160
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17149235-17161438 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.74 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96051
 protein coding gene Chr16:17149235-17161439 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022578
 protein coding gene Chr16:14476634-14488837 (+)
A/J MGP_AJ_G0022539
 protein coding gene Chr16:13756795-13768989 (+)
AKR/J MGP_AKRJ_G0022516
 protein coding gene Chr16:14300247-14312452 (+)
BALB/cJ MGP_BALBcJ_G0022542
 protein coding gene Chr16:13899340-13911544 (+)
C3H/HeJ MGP_C3HHeJ_G0022309
 protein coding gene Chr16:14438742-14450946 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022993
 protein coding gene Chr16:14705170-14717372 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020513
 protein coding gene Chr16:13828189-13841508 (+)
CAST/EiJ MGP_CASTEiJ_G0021837
 protein coding gene Chr16:14349509-14362040 (+)
CBA/J MGP_CBAJ_G0022280
 protein coding gene Chr16:15377975-15390163 (+)
DBA/2J MGP_DBA2J_G0022410
 protein coding gene Chr16:13679546-13691791 (+)
FVB/NJ MGP_FVBNJ_G0022386
 protein coding gene Chr16:13721465-13733669 (+)
LP/J MGP_LPJ_G0022477
 protein coding gene Chr16:14233730-14245938 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022407
 protein coding gene Chr16:15057452-15069656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023004
 protein coding gene Chr16:14234428-14246632 (+)
PWK/PhJ MGP_PWKPhJ_G0021580
 protein coding gene Chr16:13923022-13935479 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021408
 protein coding gene Chr16:14222402-14234706 (+)
WSB/EiJ MGP_WSBEiJ_G0021884
 protein coding gene Chr16:14240091-14252291 (+)



Homology
more
  • Human Ortholog
    SERPIND1, serpin family D member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPIND1, serpin family D member 1
  • Synonyms
    D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10
  • Links
    NCBI Gene ID: 3053
    neXtProt AC: NX_P05546
    UniProt: P05546

  • Chr Location
    22q11.21; chr22:20774113-20787720 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SERPIND1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    1
  • cDNA Data
    42
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15160 NCBI Gene Model | MGI Sequence Detail 12204 C57BL/6J ±  kb
    transcript NM_008223 RefSeq | MGI Sequence Detail 2201 ZRU/MplStud  
    polypeptide P49182 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 8
      cDNA 42

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10665, MGI:2146372, MGI:2146402
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:17526 Zhang GS, et al., Murine heparin cofactor II: purification, cDNA sequence, expression, and gene structure [published erratum appears in Biochemistry 1994 Jun 21;33(24):7744]. Biochemistry. 1994 Mar 29;33(12):3632-42
    • Latest
      J:336143 Tabata H, et al., Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome. Biomolecules. 2023 Apr 27;13(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/23/2024
    MGI 6.23     		The Jackson Laboratory