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Slc39a7 Gene Detail
Summary
  • Symbol
    Slc39a7
  • Name
    solute carrier family 39 (zinc transporter), member 7
  • Synonyms
    H-2Ke4, H2-Ke4, Ke-4, KE4, Ring5, Zip7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95909
    NCBI Gene: 14977
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34247243-34250656 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95909
 protein coding gene Chr17:34247240-34250664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023553
 protein coding gene Chr17:33997706-34001129 (-)
A/J MGP_AJ_G0023517
 protein coding gene Chr17:32820395-32823818 (-)
AKR/J MGP_AKRJ_G0023480
 protein coding gene Chr17:33234512-33237935 (-)
BALB/cJ MGP_BALBcJ_G0023519
 protein coding gene Chr17:32993195-32996619 (-)
C3H/HeJ MGP_C3HHeJ_G0023280
 protein coding gene Chr17:33588985-33592408 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023960
 protein coding gene Chr17:35299185-35302608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021438
 protein coding gene Chr17:30357858-30361228 (-)
CAST/EiJ MGP_CASTEiJ_G0022779
 protein coding gene Chr17:33688150-33692664 (-)
CBA/J MGP_CBAJ_G0023257
 protein coding gene Chr17:36697084-36700507 (-)
DBA/2J MGP_DBA2J_G0023388
 protein coding gene Chr17:32201302-32204726 (-)
FVB/NJ MGP_FVBNJ_G0023352
 protein coding gene Chr17:32070555-32073978 (-)
LP/J MGP_LPJ_G0023463
 protein coding gene Chr17:34280598-34284021 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023375
 protein coding gene Chr17:35743809-35747233 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024002
 protein coding gene Chr17:33576143-33579566 (-)
PWK/PhJ MGP_PWKPhJ_G0022529
 protein coding gene Chr17:31129880-31133303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022344
 protein coding gene Chr17:31527760-31531153 (-)
WSB/EiJ MGP_WSBEiJ_G0022840
 protein coding gene Chr17:33592044-33595468 (-)



Homology
more
  • Human Ortholog
    SLC39A7, solute carrier family 39 member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A7, solute carrier family 39 member 7
  • Synonyms
    AGM9, D6S115E, D6S2244E, H2-KE4, HKE4, KE4, RING5, ZIP7
  • Links
    NCBI Gene ID: 7922
    neXtProt AC: NX_Q92504
    UniProt: Q92504

  • Chr Location
    6p21.32; chr6:33200305-33204439 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC39A7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in intestinal epithelial cells exhibit premature death, loss of epithelial integrity, reduced enterocyte proliferation and increased enterocyte apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    57
  • cDNA Data
    184
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024327 Ensembl Gene Model | MGI Sequence Detail 3414 C57BL/6J ±  kb
    transcript ENSMUST00000025186 Ensembl | MGI Sequence Detail 2320 Not Applicable  
    polypeptide ENSMUSP00000025186 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 199
      Genomic 10
      cDNA 187
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10394, MGD-MRK-10505, MGI:2146748, MGI:2146797, MGI:2146956
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:9525 Abe K, et al., Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. EMBO J. 1988 Nov;7(11):3441-9
    • Latest
      J:282388 Anzilotti C, et al., An essential role for the Zn(2+) transporter ZIP7 in B cell development. Nat Immunol. 2019 Mar;20(3):350-361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory