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Grpr Gene Detail
Summary
  • Symbol
    Grpr
  • Name
    gastrin releasing peptide receptor
  • Synonyms
    bombesin receptor, GRP-R
Location &
Maps
more
  • Sequence Map
    ChrX:162296900-162332673 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 75.63 cM
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    745 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    3
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95836
 protein coding gene ChrX:162296900-162332732 (-)
129S1/SvImJ ENSMUSG00200026616
 protein coding gene ChrX:139024532-139060286 (-)
A/J ENSMUSG00195015244
 protein coding gene ChrX:144144926-144180705 (-)
AKR/J ENSMUSG00220029806
 protein coding gene ChrX:136003282-136051019 (-)
BALB/cJ ENSMUSG00180037487
 protein coding gene ChrX:139519553-139561941 (-)
C3H/HeJ ENSMUSG00175025069
 protein coding gene ChrX:144080573-144116323 (-)
C57BL/6NJ ENSMUSG00215014955
 protein coding gene ChrX:139914982-139950755 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033552
 protein coding gene ChrX:151824695-151860440 (-)
CAST/EiJ ENSTCUG00005033190
 protein coding gene ChrX:141641000-141676922 (-)
CBA/J ENSMUSG00210029037
 protein coding gene ChrX:141422820-141458580 (-)
DBA/2J ENSMUSG00185028526
 protein coding gene ChrX:156351464-156387224 (-)
FVB/NJ ENSMUSG00205021559
 protein coding gene ChrX:140008580-140044342 (-)
JF1/MsJ ENSUMUG00000023850
 protein coding gene ChrX:176762233-176798220 (-)
LP/J ENSMUSG00230025651
 protein coding gene ChrX:163140687-163176442 (-)
NOD/ShiLtJ ENSMUSG00190033761
 protein coding gene ChrX:140527573-140563321 (-)
NZO/HlLtJ ENSMUSG00225037894
 protein coding gene ChrX:166529996-166565759 (-)
PWK/PhJ ENSLUMG00010041248
 protein coding gene ChrX:137830380-137870496 (-)
SPRET/EiJ ENSMSPG00010017816
 protein coding gene ChrX:142987773-143023451 (-)
WSB/EiJ ENSIUOG00005024595
 protein coding gene ChrX:140928708-140972006 (-)



Homology
more
  • Human Ortholog
    GRPR, gastrin releasing peptide receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRPR, gastrin releasing peptide receptor
  • Synonyms
    BB2, BB2R, BRS2
  • Links
    NCBI Gene ID: 2925
    UniProt: P30550

  • Chr Location
    Xp22.2; chrX:16123565-16153518 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele lack bombesin-induced satiety response. Male mice hemizygous for another knock-out allele exhibit hyperactivity, abnormal social investigation, and insensitivity to gastrin-releasing peptide-induced hypothermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    22
  • cDNA Data
    8
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031364 Ensembl Gene Model | MGI Sequence Detail 35774 C57BL/6J ±  kb
transcript ENSMUST00000033730 Ensembl | MGI Sequence Detail 2523 Not Applicable  
polypeptide ENSMUSP00000033730 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 8
    Primer pair 3
    Other 4
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10276
References
more
  • Summaries
    All 130
    Developmental Gene Expression 11
    Gene Ontology 16
    Phenotypes 64
  • Earliest
    J:11093 Spindel ER, et al., Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol Endocrinol. 1990 Dec;4(12):1956-63
  • Latest
    J:377967 Roome RB, et al., Ontogeny of the spinal cord dorsal horn. Science. 2026 Jan 8;391(6781):eadx5781
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory