Grk4 MGI Mouse Gene Detail - MGI:95801 - G protein-coupled receptor kinase 4

Symbol

Grk4
Name

G protein-coupled receptor kinase 4
Synonyms

A830025H08Rik, Gprk2l

Feature Type

protein coding gene
IDs

MGI:95801
NCBI Gene: 14772
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:34817723-34912649 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.91 cM
Mapping Data

4 experiments

SNPs within 2kb

1742 from dbSNP Build 142
Strain Annotations

19
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95801	protein coding gene	Chr5:34817641-34912649 (+)
129S1/SvImJ	ENSMUSG00200028433	protein coding gene	Chr5:30286778-30381712 (+)
A/J	ENSMUSG00195046064	protein coding gene	Chr5:29757886-29852784 (+)
AKR/J	ENSMUSG00220007737	protein coding gene	Chr5:29778266-29873153 (+)
BALB/cJ	ENSMUSG00180030249	protein coding gene	Chr5:29560802-29655665 (+)
C3H/HeJ	ENSMUSG00175017760	protein coding gene	Chr5:31540352-31635235 (+)
C57BL/6NJ	ENSMUSG00215005747	protein coding gene	Chr5:30284001-30378943 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027138	protein coding gene	Chr5:29601165-29699733 (+)
CAST/EiJ	ENSTCUG00005023824	protein coding gene	Chr5:29755879-29857886 (+)
CBA/J	ENSMUSG00210004347	protein coding gene	Chr5:30509204-30604083 (+)
DBA/2J	ENSMUSG00185016009	protein coding gene	Chr5:32378687-32473591 (+)
FVB/NJ	ENSMUSG00205029966	protein coding gene	Chr5:29261057-29354064 (+)
JF1/MsJ	ENSUMUG00000029805	protein coding gene	Chr5:36974322-37069837 (+)
LP/J	ENSMUSG00230044984	protein coding gene	Chr5:36990437-37085363 (+)
NOD/ShiLtJ	ENSMUSG00190015390	protein coding gene	Chr5:29543111-29636130 (+)
NZO/HlLtJ	ENSMUSG00225015886	protein coding gene	Chr5:42196679-42291614 (+)
PWK/PhJ	ENSLUMG00010046958	protein coding gene	Chr5:29671617-29766940 (+)
SPRET/EiJ	ENSMSPG00010033373	protein coding gene	Chr5:30860264-30968773 (+)
WSB/EiJ	ENSIUOG00005016973	protein coding gene	Chr5:32469559-32564454 (+)

Human Ortholog

GRK4, G protein-coupled receptor kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRK4, G protein-coupled receptor kinase 4
Synonyms

GPRK2L, GPRK4, GRK4a, IT11
Links

HGNC:4543

NCBI Gene ID: 2868

UniProt: P32298
Chr Location

4p16.3; chr4:2963571-3040760 (+) GRCh38

MGI Vertebrate Homology

Grk4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRK4
Gene Tree

Grk4

Diseases

1 with human GRK4 associations

				Human Disease	Mouse Models
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
30 phenotype references

All Mutations and Alleles

17
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

5
Spontaneous

1
Targeted

2
Genomic Mutations

9 involving Grk4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Mice heterozygous for a knock-out allele are viable, fertile and overtly normal.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

654
Tissues

40
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grk4

ZFIN grk4

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All Sequences

73
RefSeq

32
UniProt

5
CCDS

CCDS19219.1, CCDS39070.1

Ensembl

ENSMUSG00000052783 (Evidence)
NCBI Gene

14772

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052783	Ensembl Gene Model \| MGI Sequence Detail	94927	C57BL/6J	± kb
transcript	ENSMUST00000001112	Ensembl \| MGI Sequence Detail	2408	Not Applicable
polypeptide	ENSMUSP00000001112	Ensembl \| MGI Sequence Detail	574	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008258 G protein-coupled receptor kinase 4

(term hierarchy)
EC

2.7.11.16
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR000239 GPCR kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 16

cDNA 14

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-10235, MGI:1924341

Summaries

All 69

Developmental Gene Expression 3

Diseases 1

Gene Ontology 10

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:381848 Li X, et al., LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis. Cells. 2022 Dec 9;11(24)

TSS for Grk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45897	Chr5:34817638-34817646 (+)	-81 bp
Tssr45898	Chr5:34817653-34817667 (+)	-63 bp
Tssr45899	Chr5:34817705-34817755 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24