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Gna12 Gene Detail
Summary
  • Symbol
    Gna12
  • Name
    guanine nucleotide binding protein, alpha 12
  • Synonyms
    Galpha12
  • Feature Type
    protein coding gene
  • IDs
    MGI:95767
    NCBI Gene: 14673
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140745699-140816186 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 79.30 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95767
 protein coding gene Chr5:140744163-140816186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030307
 protein coding gene Chr5:145884731-145956624 (-)
A/J MGP_AJ_G0030276
 protein coding gene Chr5:139646310-139719072 (-)
AKR/J MGP_AKRJ_G0030208
 protein coding gene Chr5:144008936-144080866 (-)
BALB/cJ MGP_BALBcJ_G0030293
 protein coding gene Chr5:140895141-140967906 (-)
C3H/HeJ MGP_C3HHeJ_G0030004
 protein coding gene Chr5:144815449-144893466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030738
 protein coding gene Chr5:151276719-151348597 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027956
 protein coding gene Chr5:133477286-133551517 (-)
CAST/EiJ MGP_CASTEiJ_G0029409
 protein coding gene Chr5:144240575-144312054 (-)
CBA/J MGP_CBAJ_G0029974
 protein coding gene Chr5:157462965-157535326 (-)
DBA/2J MGP_DBA2J_G0030124
 protein coding gene Chr5:139459352-139529078 (-)
FVB/NJ MGP_FVBNJ_G0030079
 protein coding gene Chr5:138613790-138686238 (-)
LP/J MGP_LPJ_G0030210
 protein coding gene Chr5:146490229-146561087 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030110
 protein coding gene Chr5:160059350-160131279 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030778
 protein coding gene Chr5:143848345-143920610 (-)
PWK/PhJ MGP_PWKPhJ_G0029124
 protein coding gene Chr5:138485330-138555493 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028960
 protein coding gene Chr5:141557142-141628989 (-)
WSB/EiJ MGP_WSBEiJ_G0029483
 protein coding gene Chr5:144649128-144718906 (-)



Homology
more
  • Human Ortholog
    GNA12, G protein subunit alpha 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNA12, G protein subunit alpha 12
  • Synonyms
    gep, HG1M1, NNX3, RMP
  • Links
    NCBI Gene ID: 2768
    neXtProt AC: NX_Q03113
    UniProt: Q03113

  • Chr Location
    7p22.3-p22.2; chr7:2728105-2844308 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotypes from multigenic genotypes
    46 phenotype references
Mice deficient for this gene do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    44
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    46
  • cDNA Data
    7
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14673 NCBI Gene Model | MGI Sequence Detail 70488 C57BL/6J ±  kb
transcript NM_010302 RefSeq | MGI Sequence Detail 1880 ZRU/MplStud  
polypeptide P27600 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008081 guanine nucleotide-binding protein subunit alpha-12
    (term hierarchy)
  • PDB
    1ZCA
  • InterPro Domains
    IPR000469 G-protein alpha subunit, group 12/13
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 14
    Genomic 2
    cDNA 7
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-10176, MGI:2140857, MGI:2140922
References
more
  • Summaries
    All 91
    Developmental Gene Expression 9
    Gene Ontology 13
    Phenotypes 46
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:327756 Tak J, et al., Galpha12 overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation. Theranostics. 2022;12(4):1570-1588
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory