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Gpr83 Gene Detail
Summary
  • Symbol
    Gpr83
  • Name
    G protein-coupled receptor 83
  • Synonyms
    Gir, GIR, glucocorticoid-induced receptor, Gpr72, RP105, RP39, RP82
  • Feature Type
    protein coding gene
  • IDs
    MGI:95712
    NCBI Gene: 14608
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14771506-14782085 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 4.40 cM, cytoband A2-A3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95712
 protein coding gene Chr9:14771038-14782085 (+)
129S1/SvImJ ENSMUSG00200047250
 protein coding gene Chr9:11673343-11683918 (+)
A/J ENSMUSG00195034094
 protein coding gene Chr9:11558919-11569498 (+)
AKR/J ENSMUSG00220025692
 protein coding gene Chr9:11536352-11546931 (+)
BALB/cJ ENSMUSG00180035817
 protein coding gene Chr9:11682810-11693385 (+)
C3H/HeJ ENSMUSG00175035569
 protein coding gene Chr9:11629834-11640413 (+)
C57BL/6NJ ENSMUSG00215036644
 protein coding gene Chr9:11624426-11635005 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031789
 protein coding gene Chr9:11064885-11075513 (+)
CAST/EiJ ENSTCUG00005027159
 protein coding gene Chr9:11661029-11671735 (+)
CBA/J ENSMUSG00210043456
 protein coding gene Chr9:11660799-11671378 (+)
DBA/2J ENSMUSG00185022690
 protein coding gene Chr9:11749507-11760086 (+)
FVB/NJ ENSMUSG00205021409
 protein coding gene Chr9:11733528-11744107 (+)
JF1/MsJ ENSUMUG00000015999
 protein coding gene Chr9:11732906-11743588 (+)
LP/J ENSMUSG00230038758
 protein coding gene Chr9:12171436-12182015 (+)
NOD/ShiLtJ ENSMUSG00190023194
 protein coding gene Chr9:11660026-11670605 (+)
NZO/HlLtJ ENSMUSG00225050678
 protein coding gene Chr9:12060259-12070834 (+)
PWK/PhJ ENSLUMG00010042838
 protein coding gene Chr9:11670617-11681307 (+)
SPRET/EiJ ENSMSPG00010019635
 protein coding gene Chr9:11854002-11863135 (+)
WSB/EiJ ENSIUOG00005044720
 protein coding gene Chr9:11328262-11338817 (+)



Homology
more
  • Human Ortholog
    GPR83, G protein-coupled receptor 83
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR83, G protein-coupled receptor 83
  • Synonyms
    GIR, GPR72
  • Links
    NCBI Gene ID: 10888
    UniProt: Q9NYM4

  • Chr Location
    11q21; chr11:94377316-94401419 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal regulatory T cell development. Mice homozygous for a different targeted allele exhibit attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    107
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031932 Ensembl Gene Model | MGI Sequence Detail 10580 C57BL/6J ±  kb
    transcript ENSMUST00000034408 Ensembl | MGI Sequence Detail 3586 Not Applicable  
    polypeptide ENSMUSP00000034408 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 15
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10078, MGI:2143277
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:1663 Harrigan MT, et al., Identification of a gene induced by glucocorticoids in murine T-cells: a potential G protein-coupled receptor. Mol Endocrinol. 1991 Sep;5(9):1331-8
    • Latest
      J:385919 Gomes I, et al., Identification of small molecule ligands for GPR83 that modulate morphine antinociception and reward. Mol Pharmacol. 2026 Jan;108(1):100092
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory