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Gdf10 Gene Detail
Summary
  • Symbol
    Gdf10
  • Name
    growth differentiation factor 10
  • Synonyms
    Bmp3b
  • Feature Type
    protein coding gene
  • IDs
    MGI:95684
    NCBI Gene: 14560
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33645544-33658471 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    482 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95684
 protein coding gene Chr14:33645544-33659940 (+)
129S1/SvImJ ENSMUSG00200037698
 protein coding gene Chr14:25504536-25518921 (+)
A/J ENSMUSG00195013088
 protein coding gene Chr14:26546250-26560650 (+)
AKR/J ENSMUSG00220033741
 protein coding gene Chr14:25664959-25679356 (+)
BALB/cJ ENSMUSG00180028766
 protein coding gene Chr14:25634703-25649103 (+)
C3H/HeJ ENSMUSG00175036898
 protein coding gene Chr14:25701866-25716263 (+)
C57BL/6NJ ENSMUSG00215031183
 protein coding gene Chr14:25938586-25952982 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019105
 protein coding gene Chr14:26239698-26251451 (+)
CAST/EiJ ENSTCUG00005020674
 protein coding gene Chr14:25781867-25796390 (+)
CBA/J ENSMUSG00210041994
 protein coding gene Chr14:25949059-25963459 (+)
DBA/2J ENSMUSG00185037655
 protein coding gene Chr14:30218822-30233228 (+)
FVB/NJ ENSMUSG00205016227
 protein coding gene Chr14:25806572-25820968 (+)
JF1/MsJ ENSUMUG00000044937
 protein coding gene Chr14:37494798-37509185 (+)
LP/J ENSMUSG00230036588
 protein coding gene Chr14:37531918-37546308 (+)
NOD/ShiLtJ ENSMUSG00190018705
 protein coding gene Chr14:25958659-25973462 (+)
NZO/HlLtJ ENSMUSG00225041718
 protein coding gene Chr14:31833438-31847841 (+)
PWK/PhJ ENSLUMG00010020081
 protein coding gene Chr14:14078506-14092943 (+)
SPRET/EiJ ENSMSPG00010042002
 protein coding gene Chr14:27643524-27656826 (+)
WSB/EiJ ENSIUOG00005011293
 protein coding gene Chr14:25790720-25805530 (+)



Homology
more
  • Human Ortholog
    GDF10, growth differentiation factor 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF10, growth differentiation factor 10
  • Synonyms
    BIP, BMP-3b, BMP3B
  • Links
    NCBI Gene ID: 2662
    UniProt: P55107

  • Chr Location
    10q11.22; chr10:47300171-47313577 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    134
  • cDNA Data
    25
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14560 NCBI Gene Model | MGI Sequence Detail 12928 C57BL/6J ±  kb
    transcript NM_145741 RefSeq | MGI Sequence Detail 3741 ZRU/MplStud  
    polypeptide P97737 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007918 bone morphogenetic protein 3B
      (term hierarchy)
    • InterPro Domains
      IPR017197 Bone morphogenetic protein 3/3B
      IPR029034 Cystine-knot cytokine
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-like
    • GlyGen
      P97737 4 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 25
      Primer pair 6
      Other 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10037
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 35
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:29417 Cunningham NS, et al., Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3. Growth Factors. 1995;12(2):99-109
    • Latest
      J:374458 Kokabu S, et al., Excessive BMP3b suppresses skeletal muscle differentiation. Biochem Biophys Res Commun. 2025 Feb;746:151261
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory