About   Help   FAQ
Gabrr1 Gene Detail
Summary
  • Symbol
    Gabrr1
  • Name
    gamma-aminobutyric acid type A receptor subunit rho 1
  • Synonyms
    GABA-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:95625
    NCBI Gene: 14408
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33132556-33163606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.68 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95625
 protein coding gene Chr4:33132521-33163606 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028119
 protein coding gene Chr4:30633847-30668612 (+)
A/J MGP_AJ_G0028077
 protein coding gene Chr4:29539670-29571569 (+)
AKR/J MGP_AKRJ_G0028040
 protein coding gene Chr4:30308864-30339798 (+)
BALB/cJ MGP_BALBcJ_G0028088
 protein coding gene Chr4:29798542-29829481 (+)
C3H/HeJ MGP_C3HHeJ_G0027817
 protein coding gene Chr4:30607067-30638955 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028530
 protein coding gene Chr4:31838111-31873699 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025871
 protein coding gene Chr4:27599831-27631888 (+)
CAST/EiJ MGP_CASTEiJ_G0027272
 protein coding gene Chr4:30381004-30416036 (+)
CBA/J MGP_CBAJ_G0027789
 protein coding gene Chr4:32862832-32897964 (+)
DBA/2J MGP_DBA2J_G0027933
 protein coding gene Chr4:29539903-29571341 (+)
FVB/NJ MGP_FVBNJ_G0027899
 protein coding gene Chr4:28971418-29002053 (+)
LP/J MGP_LPJ_G0028041
 protein coding gene Chr4:30722564-30755005 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027932
 protein coding gene Chr4:35443765-35477357 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028589
 protein coding gene Chr4:30319457-30351469 (+)
PWK/PhJ MGP_PWKPhJ_G0026991
 protein coding gene Chr4:29548023-29577383 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026820
 protein coding gene Chr4:30208519-30240267 (+)
WSB/EiJ MGP_WSBEiJ_G0027348
 protein coding gene Chr4:30324366-30354750 (+)



Homology
more
  • Human Ortholog
    GABRR1, gamma-aminobutyric acid type A receptor subunit rho1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRR1, gamma-aminobutyric acid type A receptor subunit rho1
  • Links
    NCBI Gene ID: 2569
    neXtProt AC: NX_P24046
    UniProt: P24046

  • Chr Location
    6q15; chr6:89177504-89231288 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display altered visual processing in the retina. Mice homozygous for a different knock-out allele exhibit alterations of mechanical pain sensitivity, GABA-inhibited spinal cord responses, and olfactory function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14408 NCBI Gene Model | MGI Sequence Detail 31051 C57BL/6J ±  kb
transcript NM_008075 RefSeq | MGI Sequence Detail 2280 Not Specified  
polypeptide P56475 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007782 gamma-aminobutyric acid receptor subunit rho-1
    (term hierarchy)
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008057 Gamma-aminobutyric-acid A receptor, Rho
    IPR008058 Gamma-aminobutyric-acid A receptor, Rho1
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9944
References
more
  • Summaries
    All 52
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:2295 Cutting GR, et al., Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 1992 Apr;12(4):801-6
  • Latest
    J:332132 Cattaneo P, et al., DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Nat Commun. 2022 Dec 2;13(1):7444
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory