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Gabrg3 Gene Detail
Summary
  • Symbol
    Gabrg3
  • Name
    gamma-aminobutyric acid type A receptor, subunit gamma 3
  • Synonyms
    B230362M20Rik, Gabrg-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95624
    NCBI Gene: 14407
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:56366213-57036936 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 33.48 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6584 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95624
 protein coding gene Chr7:56366211-57037173 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032318
 protein coding gene Chr7:57521048-58204710 (-)
A/J MGP_AJ_G0032297
 protein coding gene Chr7:56654316-57322742 (-)
AKR/J MGP_AKRJ_G0032233
 protein coding gene Chr7:57955917-58649756 (-)
BALB/cJ MGP_BALBcJ_G0032309
 protein coding gene Chr7:56255681-56908735 (-)
C3H/HeJ MGP_C3HHeJ_G0032022
 protein coding gene Chr7:58298529-58996404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032802
 protein coding gene Chr7:60120850-60838880 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029809
 protein coding gene Chr7:59274920-59893967 (-)
CAST/EiJ MGP_CASTEiJ_G0031351
 protein coding gene Chr7:49518274-50172430 (-)
CBA/J MGP_CBAJ_G0031987
 protein coding gene Chr7:62218546-62942435 (-)
DBA/2J MGP_DBA2J_G0032144
 protein coding gene Chr7:55678507-56318037 (-)
FVB/NJ MGP_FVBNJ_G0032098
 protein coding gene Chr7:55604649-56260534 (-)
LP/J MGP_LPJ_G0032225
 protein coding gene Chr7:58603501-59315949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032135
 protein coding gene Chr7:61742112-62527517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032819
 protein coding gene Chr7:56969601-57648293 (-)
PWK/PhJ MGP_PWKPhJ_G0031071
 protein coding gene Chr7:48918396-49535507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030912
 protein coding gene Chr7:44987561-45688677 (-)
WSB/EiJ MGP_WSBEiJ_G0031469
 protein coding gene Chr7:57591611-58253643 (-)



Homology
more
  • Human Ortholog
    GABRG3, gamma-aminobutyric acid type A receptor subunit gamma3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRG3, gamma-aminobutyric acid type A receptor subunit gamma3
  • Links
    NCBI Gene ID: 2567
    neXtProt AC: NX_Q99928
    UniProt: Q99928

  • Chr Location
    15q12; chr15:26971181-27541984 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    14
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055026 Ensembl Gene Model | MGI Sequence Detail 670724 C57BL/6J ±  kb
    transcript ENSMUST00000068911 Ensembl | MGI Sequence Detail 9767 Not Applicable  
    polypeptide ENSMUSP00000067632 Ensembl | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007779 gamma-aminobutyric acid receptor subunit gamma-3
      (term hierarchy)
    • InterPro Domains
      IPR005440 Gamma-aminobutyric-acid A receptor, gamma 3 subunit
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR005437 Gamma-aminobutyric acid receptor subunit gamma-1/4
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9941, MGD-MRK-9943, MGI:2444828
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 5
      Diseases 4
      Gene Ontology 8
      Phenotypes 59
    • Earliest
      J:263492 Sulpizio A, et al., Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Life Sci. 1978 Apr 24;22(16):1439-46
    • Latest
      J:335224 Nakai N, et al., Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism. Cell Rep. 2023 Mar 24;:112258
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory