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Gabpa Gene Detail
Summary
  • Symbol
    Gabpa
  • Name
    GA repeat binding protein, alpha
  • Synonyms
    GABPalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95610
    NCBI Gene: 14390
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84631813-84660667 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3-4
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    794 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95610
 protein coding gene Chr16:84631795-84660671 (+)
129S1/SvImJ ENSMUSG00200037513
 protein coding gene Chr16:81531273-81560144 (+)
A/J ENSMUSG00195022561
 protein coding gene Chr16:81325843-81354785 (+)
AKR/J ENSMUSG00220017584
 protein coding gene Chr16:81479415-81508264 (+)
BALB/cJ ENSMUSG00180002040
 protein coding gene Chr16:81368057-81396818 (+)
C3H/HeJ ENSMUSG00175014927
 protein coding gene Chr16:81681135-81710074 (+)
C57BL/6NJ ENSMUSG00215021198
 protein coding gene Chr16:81494085-81522938 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020891
 protein coding gene Chr16:79471442-79500439 (+)
CAST/EiJ ENSTCUG00005007222
 protein coding gene Chr16:81151744-81180674 (+)
CBA/J ENSMUSG00210033012
 protein coding gene Chr16:81593504-81622266 (+)
DBA/2J ENSMUSG00185005058
 protein coding gene Chr16:81537710-81566654 (+)
FVB/NJ ENSMUSG00205013336
 protein coding gene Chr16:81354365-81383303 (+)
JF1/MsJ ENSUMUG00000025457
 protein coding gene Chr16:81677517-81706268 (+)
LP/J ENSMUSG00230033534
 protein coding gene Chr16:84091166-84120039 (+)
NOD/ShiLtJ ENSMUSG00190020988
 protein coding gene Chr16:81543082-81572021 (+)
NZO/HlLtJ ENSMUSG00225030532
 protein coding gene Chr16:87224116-87252859 (+)
PWK/PhJ ENSLUMG00010004828
 protein coding gene Chr16:81332651-81358943 (+)
SPRET/EiJ ENSMSPG00010029456
 protein coding gene Chr16:82297539-82330108 (+)
WSB/EiJ ENSIUOG00005016840
 protein coding gene Chr16:81470069-81498946 (+)



Homology
more
  • Human Ortholog
    GABPA, GA binding protein transcription factor subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABPA, GA binding protein transcription factor subunit alpha
  • Synonyms
    E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
  • Links
    NCBI Gene ID: 2551
    UniProt: Q06546

  • Chr Location
    21q21.3; chr21:25734570-25772460 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 6 alleles in 5 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die early in embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    243
  • cDNA Data
    134
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008976 Ensembl Gene Model | MGI Sequence Detail 28855 C57BL/6J ±  kb
    transcript ENSMUST00000114184 Ensembl | MGI Sequence Detail 2202 Not Applicable  
    polypeptide ENSMUSP00000109822 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      Genomic 2
      cDNA 136
      Primer pair 6
      Other 4
      Antibodies 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9919
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 16
      Phenotypes 37
    • Earliest
      J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
    • Latest
      J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory