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Fshb Gene Detail
Summary
  • Symbol
    Fshb
  • Name
    follicle stimulating hormone beta
  • Synonyms
    FSH, Fshbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:95582
    NCBI Gene: 14308
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
  • Regulated by
    Rr466 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr2:106886485-106890001 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 56.02 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95582
 protein coding gene Chr2:106886331-106890001 (-)
129S1/SvImJ ENSMUSG00200007360
 protein coding gene Chr2:103734925-103738427 (-)
A/J ENSMUSG00195030162
 protein coding gene Chr2:103886647-103890163 (-)
AKR/J ENSMUSG00220004953
 protein coding gene Chr2:103631971-103635489 (-)
BALB/cJ ENSMUSG00180028880
 protein coding gene Chr2:103681944-103685464 (-)
C3H/HeJ ENSMUSG00175027472
 protein coding gene Chr2:104005621-104009122 (-)
C57BL/6NJ ENSMUSG00215016310
 protein coding gene Chr2:103776168-103779684 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024043
 protein coding gene Chr2:100504578-100508060 (-)
CAST/EiJ ENSTCUG00005005413
 protein coding gene Chr2:103054809-103058312 (-)
CBA/J ENSMUSG00210038101
 protein coding gene Chr2:103959582-103963100 (-)
DBA/2J ENSMUSG00185036816
 protein coding gene Chr2:103678458-103681976 (-)
FVB/NJ ENSMUSG00205018101
 protein coding gene Chr2:103006721-103010223 (-)
JF1/MsJ ENSUMUG00000003596
 protein coding gene Chr2:103415524-103419025 (-)
LP/J ENSMUSG00230004315
 protein coding gene Chr2:105426732-105430234 (-)
NOD/ShiLtJ ENSMUSG00190014328
 protein coding gene Chr2:103803854-103807356 (-)
NZO/HlLtJ ENSMUSG00225012321
 protein coding gene Chr2:113326542-113330044 (-)
PWK/PhJ ENSLUMG00010002886
 protein coding gene Chr2:103415754-103419255 (-)
SPRET/EiJ ENSMSPG00010036363
 protein coding gene Chr2:105492384-105494994 (-)
WSB/EiJ ENSIUOG00005029946
 protein coding gene Chr2:103469422-103472944 (-)



Homology
more
  • Human Ortholog
    FSHB, follicle stimulating hormone subunit beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSHB, follicle stimulating hormone subunit beta
  • Synonyms
    HH24
  • Links
    NCBI Gene ID: 2488
    UniProt: P01225

  • Chr Location
    11p14.1; chr11:30231014-30235261 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FSHB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Females homozygous for a targeted null mutation are sterile with a preantral block in folliculogenesis. Mutant males have small testes and reduced Sertoli and germ cell numbers, but are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    17
  • cDNA Data
    55
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027120 Ensembl Gene Model | MGI Sequence Detail 3517 C57BL/6J ±  kb
    transcript ENSMUST00000028533 Ensembl | MGI Sequence Detail 1600 Not Applicable  
    polypeptide ENSMUSP00000028533 Ensembl | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 3
      cDNA 57
      Primer pair 6
      Other 3
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9875
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 60
      Gene Ontology 14
      Phenotypes 40
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:378415 Brewer KM, et al., Primary cilia and BBS4 are required for postnatal pituitary development. Dev Biol. 2026 Jan 7;532:20-31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory