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Fgg Gene Detail
Summary
  • Symbol
    Fgg
  • Name
    fibrinogen gamma chain
  • Synonyms
    3010002H13Rik, gamma-fibrinogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95526
    NCBI Gene: 99571
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82915031-82922356 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 36.94 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95526
 protein coding gene Chr3:82915031-82922363 (+)
129S1/SvImJ ENSMUSG00200019086
 protein coding gene Chr3:79747952-79755250 (+)
A/J ENSMUSG00195011441
 protein coding gene Chr3:79764181-79771455 (+)
AKR/J ENSMUSG00220001306
 protein coding gene Chr3:79724227-79731553 (+)
BALB/cJ ENSMUSG00180001855
 protein coding gene Chr3:79897025-79904355 (+)
C3H/HeJ ENSMUSG00175007206
 protein coding gene Chr3:79690810-79698082 (+)
C57BL/6NJ ENSMUSG00215001939
 protein coding gene Chr3:80155116-80162443 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025103
 protein coding gene Chr3:75821486-75828877 (+)
CAST/EiJ ENSTCUG00005001852
 protein coding gene Chr3:79248648-79255946 (+)
CBA/J ENSMUSG00210025345
 protein coding gene Chr3:79835524-79842796 (+)
DBA/2J ENSMUSG00185012525
 protein coding gene Chr3:79981682-79989012 (+)
FVB/NJ ENSMUSG00205006088
 protein coding gene Chr3:78765101-78772428 (+)
JF1/MsJ ENSUMUG00000001297
 protein coding gene Chr3:79557818-79565192 (+)
LP/J ENSMUSG00230028428
 protein coding gene Chr3:81956466-81963764 (+)
NOD/ShiLtJ ENSMUSG00190002611
 protein coding gene Chr3:80210532-80217861 (+)
NZO/HlLtJ ENSMUSG00225007426
 protein coding gene Chr3:84700478-84707752 (+)
PWK/PhJ ENSLUMG00010006338
 protein coding gene Chr3:79607075-79614372 (+)
SPRET/EiJ ENSMSPG00010017167
 protein coding gene Chr3:80392961-80400280 (+)
WSB/EiJ ENSIUOG00005002870
 protein coding gene Chr3:80188729-80196042 (+)



Homology
more
  • Human Ortholog
    FGG, fibrinogen gamma chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGG, fibrinogen gamma chain
  • Links
    NCBI Gene ID: 2266
    UniProt: P02679

  • Chr Location
    4q32.1; chr4:154604134-154612967 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgg mouse models; 4 with human FGG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    54
  • cDNA Data
    10
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033860 Ensembl Gene Model | MGI Sequence Detail 7326 C57BL/6J ±  kb
    transcript ENSMUST00000194175 Ensembl | MGI Sequence Detail 1741 Not Applicable  
    polypeptide ENSMUSP00000141648 Ensembl | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007507 fibrinogen gamma chain
      (term hierarchy)
    • InterPro Domains
      IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR037579 Fibrinogen/angiopoietin-like
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      Q8VCM7 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 2
      Other 1
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9786, MGI:1924212, MGI:2139652
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 12
      Phenotypes 61
    • Earliest
      J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
    • Latest
      J:380652 Li J, et al., Fibrin induces infiltration of macrophages and neutrophils via integrin alphaMbeta2 and triggers aortic dissection. Br J Pharmacol. 2025 Aug;182(15):3577-3593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory