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Ptk2 Gene Detail
Summary
  • Symbol
    Ptk2
  • Name
    PTK2 protein tyrosine kinase 2
  • Synonyms
    Fadk, FAK, FRNK
  • Feature Type
    protein coding gene
  • IDs
    MGI:95481
    NCBI Gene: 14083
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:73076951-73295129 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 33.94 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    607 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95481
 protein coding gene Chr15:73076951-73297192 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021920
 protein coding gene Chr15:72918046-73157563 (-)
A/J MGP_AJ_G0021879
 protein coding gene Chr15:70315839-70533266 (-)
AKR/J MGP_AKRJ_G0021861
 protein coding gene Chr15:72111377-72343146 (-)
BALB/cJ MGP_BALBcJ_G0021886
 protein coding gene Chr15:70333464-70551899 (-)
C3H/HeJ MGP_C3HHeJ_G0021659
 protein coding gene Chr15:72265822-72497538 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022325
 protein coding gene Chr15:75709168-75941745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019862
 protein coding gene Chr15:66773027-66925276 (-)
CAST/EiJ MGP_CASTEiJ_G0021178
 protein coding gene Chr15:73021244-73282698 (-)
CBA/J MGP_CBAJ_G0021625
 protein coding gene Chr15:78170938-78414514 (-)
DBA/2J MGP_DBA2J_G0021750
 protein coding gene Chr15:69931555-70148753 (-)
FVB/NJ MGP_FVBNJ_G0021732
 protein coding gene Chr15:68932641-69151719 (-)
LP/J MGP_LPJ_G0021822
 protein coding gene Chr15:72950269-73180227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021755
 protein coding gene Chr15:83549483-83792461 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022347
 protein coding gene Chr15:72516216-72743411 (-)
PWK/PhJ MGP_PWKPhJ_G0020919
 protein coding gene Chr15:70025356-70241050 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020760
 protein coding gene Chr15:72394647-72625903 (-)
WSB/EiJ MGP_WSBEiJ_G0021230
 protein coding gene Chr15:72502109-72731654 (-)



Homology
more
  • Human Ortholog
    PTK2, protein tyrosine kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTK2, protein tyrosine kinase 2
  • Synonyms
    FADK, FADK 1, FAK, FAK1, FRNK, p125FAK, pp125FAK, PPP1R71
  • Links
    NCBI Gene ID: 5747
    neXtProt AC: NX_Q05397
    UniProt: Q05397

  • Chr Location
    8q24.3; chr8:140657900-141002216 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PTK2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 13 alleles in 17 genetic backgrounds
    7 phenotypes from multigenic genotypes
    6 images
    163 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    160
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1305
  • Tissues
    264
  • cDNA Data
    163
  • Literature Summary
    84
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022607 Ensembl Gene Model | MGI Sequence Detail 218179 C57BL/6J ±  kb
    transcript ENSMUST00000239146 Ensembl | MGI Sequence Detail 4540 Not Applicable  
    polypeptide ENSMUSP00000159174 Ensembl | MGI Sequence Detail 1093 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      Genomic 1
      cDNA 166
      Primer pair 15
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-9708
    References
    more
    • Summaries
      All 404
      Developmental Gene Expression 84
      Diseases 1
      Gene Ontology 39
      Phenotypes 163
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:335821 Gao G, et al., Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development. Nat Commun. 2023 Apr 25;14(1):2378
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory