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Eno1 Gene Detail
Summary
  • Symbol
    Eno1
  • Name
    enolase 1, alpha non-neuron
  • Synonyms
    2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, Eno-1, MBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95393
    NCBI Gene: 13806
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:150321178-150333336 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 81.24 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95393
 protein coding gene Chr4:150321165-150333336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029153
 protein coding gene Chr4:154187546-154201440 (+)
A/J MGP_AJ_G0029118
 protein coding gene Chr4:147720595-147733337 (+)
AKR/J MGP_AKRJ_G0029066
 protein coding gene Chr4:151776648-151789197 (+)
BALB/cJ MGP_BALBcJ_G0029134
 protein coding gene Chr4:148219109-148231392 (+)
C3H/HeJ MGP_C3HHeJ_G0028855
 protein coding gene Chr4:152317640-152330219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029583
 protein coding gene Chr4:159732583-159748326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026829
 protein coding gene Chr4:140129922-140142194 (+)
CAST/EiJ MGP_CASTEiJ_G0028268
 protein coding gene Chr4:149582219-149597493 (+)
CBA/J MGP_CBAJ_G0028817
 protein coding gene Chr4:164439922-164470290 (+)
DBA/2J MGP_DBA2J_G0028966
 protein coding gene Chr4:147811016-147822932 (+)
FVB/NJ MGP_FVBNJ_G0028930
 protein coding gene Chr4:146941907-146955903 (+)
LP/J MGP_LPJ_G0029056
 protein coding gene Chr4:154109655-154130557 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028957
 protein coding gene Chr4:167587980-167599978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029615
 protein coding gene Chr4:152281893-152295389 (+)
PWK/PhJ MGP_PWKPhJ_G0027988
 protein coding gene Chr4:143837021-143850189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027822
 protein coding gene Chr4:146542799-146554869 (+)
WSB/EiJ MGP_WSBEiJ_G0028348
 protein coding gene Chr4:152419942-152436682 (+)



Homology
more
  • Human Ortholog
    ENO1, enolase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENO1, enolase 1
  • Synonyms
    ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
  • Links
    NCBI Gene ID: 2023
    neXtProt AC: NX_P06733
    UniProt: P06733

  • Chr Location
    1p36.23; chr1:8861000-8879190 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ENO1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous animals exhibit growth arrest and embryonic lethality at approximately E6.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    990
  • Tissues
    162
  • cDNA Data
    29
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063524 Ensembl Gene Model | MGI Sequence Detail 12159 C57BL/6J ±  kb
    transcript ENSMUST00000080926 Ensembl | MGI Sequence Detail 2027 Not Applicable  
    polypeptide ENSMUSP00000079727 Ensembl | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 33
      Primer pair 1
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-9503, MGD-MRK-9506, MGI:2143710
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 28
      Gene Ontology 15
      Phenotypes 12
    • Earliest
      J:5856 D'Ancona GG, et al., Assignment of the gene for enolase to mouse chromosome 4 using somatic cell hybrids. Cytogenet Cell Genet. 1977;19(1):1-6
    • Latest
      J:337927 Kawakami H, et al., Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. Dev Biol. 2023 Sep;501:28-38
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory