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Eif4a1 Gene Detail
Summary
  • Symbol
    Eif4a1
  • Name
    eukaryotic translation initiation factor 4A1
  • Synonyms
    Eif4, initiation factor eIF-4A long form
  • Feature Type
    protein coding gene
  • IDs
    MGI:95303
    NCBI Gene: 13681
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69557762-69563249 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95303
 protein coding gene Chr11:69557762-69563249 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018546
 protein coding gene Chr11:70123842-70131437 (-)
A/J MGP_AJ_G0018514
 protein coding gene Chr11:67482952-67488455 (-)
AKR/J MGP_AKRJ_G0018483
 protein coding gene Chr11:69491729-69497216 (-)
BALB/cJ MGP_BALBcJ_G0018486
 protein coding gene Chr11:67792674-67798162 (-)
C3H/HeJ MGP_C3HHeJ_G0018299
 protein coding gene Chr11:69512292-69529590 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018937
 protein coding gene Chr11:72246701-72252283 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016582
 protein coding gene Chr11:64402376-64407965 (-)
CAST/EiJ MGP_CASTEiJ_G0017854
 protein coding gene Chr11:69763681-69769182 (-)
CBA/J MGP_CBAJ_G0018272
 protein coding gene Chr11:75480779-75488859 (-)
DBA/2J MGP_DBA2J_G0018381
 protein coding gene Chr11:67063953-67071360 (-)
FVB/NJ MGP_FVBNJ_G0018371
 protein coding gene Chr11:66700760-66713791 (-)
LP/J MGP_LPJ_G0018451
 protein coding gene Chr11:70690907-70697986 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018394
 protein coding gene Chr11:76073893-76079380 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018979
 protein coding gene Chr11:69755273-69760710 (-)
PWK/PhJ MGP_PWKPhJ_G0017628
 protein coding gene Chr11:67714374-67721496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017418
 protein coding gene Chr11:69568980-69580731 (-)
WSB/EiJ MGP_WSBEiJ_G0017908
 protein coding gene Chr11:69426996-69432605 (-)



Homology
more
  • Human Ortholog
    EIF4A1, eukaryotic translation initiation factor 4A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4A1, eukaryotic translation initiation factor 4A1
  • Synonyms
    DDX2A, EIF4A, EIF-4A, eIF-4A-I, eIF4A-I
  • Links
    NCBI Gene ID: 1973
    neXtProt AC: NX_P60842
    UniProt: P60842

  • Chr Location
    17p13.1; chr17:7572824-7579006 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    9
  • Targeted
    2
  • Genomic Mutations
    2 involving Eif4a1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    27
  • cDNA Data
    41
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13681 NCBI Gene Model | MGI Sequence Detail 5488 C57BL/6J ±  kb
transcript NM_144958 RefSeq | MGI Sequence Detail 1897 ZRU/MplStud  
polypeptide P60843 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    Genomic 4
    cDNA 42
    Primer pair 2
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-9336, MGD-MRK-9337
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:344730 Screen M, et al., RNA helicase EIF4A1-mediated translation is essential for the GC response. Life Sci Alliance. 2024 Feb;7(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory