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Eed Gene Detail
Summary
  • Symbol
    Eed
  • Name
    embryonic ectoderm development
  • Synonyms
    l(7)5Rn, l7Rn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95286
    NCBI Gene: 13626
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89603862-89630184 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 50.42 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95286
 protein coding gene Chr7:89603862-89630191 (-)
129S1/SvImJ ENSMUSG00200026078
 protein coding gene Chr7:76366841-76393169 (-)
A/J ENSMUSG00195039836
 protein coding gene Chr7:80891499-80917889 (-)
AKR/J ENSMUSG00220041094
 protein coding gene Chr7:74361766-74388153 (-)
BALB/cJ ENSMUSG00180034928
 protein coding gene Chr7:77568425-77594817 (-)
C3H/HeJ ENSMUSG00175031702
 protein coding gene Chr7:78255462-78281784 (-)
C57BL/6NJ ENSMUSG00215013355
 protein coding gene Chr7:77439617-77465949 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029979
 protein coding gene Chr7:93031518-93058459 (-)
CAST/EiJ ENSTCUG00005031602
 protein coding gene Chr7:80875440-80902123 (-)
CBA/J ENSMUSG00210034271
 protein coding gene Chr7:78097408-78123729 (-)
DBA/2J ENSMUSG00185031504
 protein coding gene Chr7:82426996-82453314 (-)
FVB/NJ ENSMUSG00205026657
 protein coding gene Chr7:78042608-78069176 (-)
JF1/MsJ ENSUMUG00000008978
 protein coding gene Chr7:87365828-87392386 (-)
LP/J ENSMUSG00230013826
 protein coding gene Chr7:88516459-88542778 (-)
NOD/ShiLtJ ENSMUSG00190023193
 protein coding gene Chr7:78312486-78338879 (-)
NZO/HlLtJ ENSMUSG00225010333
 protein coding gene Chr7:86791235-86817554 (-)
PWK/PhJ ENSLUMG00010034677
 protein coding gene Chr7:76569610-76596120 (-)
SPRET/EiJ ENSMSPG00010012143
 protein coding gene Chr7:77612086-77639758 (-)
WSB/EiJ ENSIUOG00005031445
 protein coding gene Chr7:78686285-78712598 (-)



Homology
more
  • Human Ortholog
    EED, embryonic ectoderm development
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EED, embryonic ectoderm development
  • Synonyms
    COGIS, HEED, WAIT1
  • Links
    NCBI Gene ID: 8726
    UniProt: O75530

  • Chr Location
    11q14.2; chr11:86201212-86287615 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    108
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    84
  • Radiation induced
    3
  • Targeted
    13
  • Genomic Mutations
    4 involving Eed
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    117 strains or lines available
Homozygous mutant mice are dwarfed and their coat color is dilute.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    113
  • cDNA Data
    93
  • Literature Summary
    47
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13626 NCBI Gene Model | MGI Sequence Detail 26323 C57BL/6J ±  kb
transcript NM_021876 RefSeq | MGI Sequence Detail 2060 C57BL/6  
polypeptide Q921E6 UniProt | EBI | MGI Sequence Detail 441 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 112
    Genomic 4
    cDNA 95
    Primer pair 4
    Other 9
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11693, MGD-MRK-11725, MGD-MRK-9305, MGI:3584396, MGI:3641985, MGI:96737
References
more
  • Summaries
    All 271
    Developmental Gene Expression 47
    Gene Ontology 38
    Phenotypes 134
  • Earliest
    J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
  • Latest
    J:391356 Li MY, et al., Oncogenic Ras drives EED degradation and PRC2 dysfunction to promote aggressive squamous cell carcinoma. Nat Commun. 2026 Jul 13;17(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory