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Dpp6 Gene Detail
Summary
  • Symbol
    Dpp6
  • Name
    dipeptidylpeptidase 6
  • Synonyms
    B930011P16Rik, Dpp-6, In(5)6H-p, LOC384168, Peplb, Rw
  • Feature Type
    protein coding gene
  • IDs
    MGI:94921
    NCBI Gene: 13483
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:27022355-27932498 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 12.92 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28375 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94921
 protein coding gene Chr5:27022201-27932503 (+)
129S1/SvImJ ENSMUSG00200011550
 protein coding gene Chr5:22529605-23431975 (+)
A/J ENSMUSG00195043931
 protein coding gene Chr5:21978028-22888914 (+)
AKR/J ENSMUSG00220006959
 protein coding gene Chr5:21982967-22896577 (+)
BALB/cJ ENSMUSG00180032320
 protein coding gene Chr5:21782645-22693542 (+)
C3H/HeJ ENSMUSG00175044331
 protein coding gene Chr5:23756944-24668030 (+)
C57BL/6NJ ENSMUSG00215035480
 protein coding gene Chr5:22538245-23448681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027033
 protein coding gene Chr5:21473360-22401140 (+)
CAST/EiJ ENSTCUG00005021531
 protein coding gene Chr5:22011111-22919762 (+)
CBA/J ENSMUSG00210041088
 protein coding gene Chr5:22724107-23641344 (+)
DBA/2J ENSMUSG00185031766
 protein coding gene Chr5:24574498-25484943 (+)
FVB/NJ ENSMUSG00205029157
 protein coding gene Chr5:21551983-22468324 (+)
JF1/MsJ ENSUMUG00000004670
 protein coding gene Chr5:29129992-30048020 (+)
LP/J ENSMUSG00230024477
 protein coding gene Chr5:29215116-30117383 (+)
NOD/ShiLtJ ENSMUSG00190012064
 protein coding gene Chr5:21836163-22746610 (+)
NZO/HlLtJ ENSMUSG00225019463
 protein coding gene Chr5:34428002-35338789 (+)
PWK/PhJ ENSLUMG00010047489
 protein coding gene Chr5:21909911-22815229 (+)
SPRET/EiJ ENSMSPG00010034008
 protein coding gene Chr5:22967841-23914451 (+)
WSB/EiJ ENSIUOG00005038488
 protein coding gene Chr5:24691815-25608493 (+)



Homology
more
  • Human Ortholog
    DPP6, dipeptidyl peptidase like 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPP6, dipeptidyl peptidase like 6
  • Synonyms
    DPL1, DPPX, MRD33, VF2
  • Links
    NCBI Gene ID: 1804
    UniProt: P42658

  • Chr Location
    7q36.2; chr7:153748133-154894285 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human DPP6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    3
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    7 involving Dpp6
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    57 strains or lines available
Mice homozygous for a knock-out allele exhibit loss of A-type K+ current gradients in distal dendrites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    138
  • cDNA Data
    56
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13483 NCBI Gene Model | MGI Sequence Detail 910144 C57BL/6J ±  kb
transcript NM_010075 RefSeq | MGI Sequence Detail 4866 C57BL/6  
polypeptide Q9Z218 UniProt | EBI | MGI Sequence Detail 804 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000006661 A-type potassium channel modulatory protein DPP6
    (term hierarchy)
  • PDB
    7W6T
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR002469 Dipeptidylpeptidase IV, N-terminal domain
    IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
    IPR050278 Serine protease S9B/DPPIV
  • GlyGen
    Q9Z218 10 sites, 43 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 66
    Genomic 1
    cDNA 60
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16624, MGD-MRK-8886, MGD-MRK-8889, MGI:1349384, MGI:2686223
References
more
  • Summaries
    All 102
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 12
    Phenotypes 42
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:388126 Hernandez M, et al., Dpp6 knockout mice exhibit increased ethanol conditioned place preference and acute ethanol-induced anxiolytic behavior. Alcohol Clin Exp Res (Hoboken). 2026 Apr;50(4):e70282
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory