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Cyb5r3 Gene Detail
Summary
  • Symbol
    Cyb5r3
  • Name
    cytochrome b5 reductase 3
  • Synonyms
    0610016L08Rik, 2500002N19Rik, Dia1, Dia-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94893
    NCBI Gene: 109754
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83037695-83056793 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.40 cM, cytoband E
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94893
 protein coding gene Chr15:83037695-83060641 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022160
 protein coding gene Chr15:83819428-83837858 (-)
A/J MGP_AJ_G0022119
 protein coding gene Chr15:80767604-80788916 (-)
AKR/J MGP_AKRJ_G0022094
 protein coding gene Chr15:83082512-83102898 (-)
BALB/cJ MGP_BALBcJ_G0022125
 protein coding gene Chr15:80912275-80931196 (-)
C3H/HeJ MGP_C3HHeJ_G0021895
 protein coding gene Chr15:83079782-83101483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022570
 protein coding gene Chr15:87056652-87080216 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020094
 protein coding gene Chr15:77152435-77170771 (-)
CAST/EiJ MGP_CASTEiJ_G0021417
 protein coding gene Chr15:83814408-83845898 (-)
CBA/J MGP_CBAJ_G0021862
 protein coding gene Chr15:89804303-89829876 (-)
DBA/2J MGP_DBA2J_G0021989
 protein coding gene Chr15:80260082-80279231 (-)
FVB/NJ MGP_FVBNJ_G0021968
 protein coding gene Chr15:79296289-79318551 (-)
LP/J MGP_LPJ_G0022060
 protein coding gene Chr15:83994035-84014979 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021988
 protein coding gene Chr15:94732805-94762181 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022585
 protein coding gene Chr15:83127217-83146572 (-)
PWK/PhJ MGP_PWKPhJ_G0021158
 protein coding gene Chr15:80235687-80255420 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020992
 protein coding gene Chr15:82842579-82861066 (-)
WSB/EiJ MGP_WSBEiJ_G0021466
 protein coding gene Chr15:83616390-83636816 (-)



Homology
more
  • Human Ortholog
    CYB5R3, cytochrome b5 reductase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYB5R3, cytochrome b5 reductase 3
  • Synonyms
    B5R, DIA1
  • Links
    NCBI Gene ID: 1727
    neXtProt AC: NX_P00387
    UniProt: P00387

  • Chr Location
    22q13.2; chr22:42615730-42720870 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CYB5R3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    137
  • cDNA Data
    237
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018042 Ensembl Gene Model | MGI Sequence Detail 19099 C57BL/6J ±  kb
    transcript ENSMUST00000162178 Ensembl | MGI Sequence Detail 2547 Not Applicable  
    polypeptide ENSMUSP00000125636 Ensembl | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006082 NADH-cytochrome b5 reductase 3
      (term hierarchy)
    • EC
      1.6.2.2
    • InterPro Domains
      IPR017927 FAD-binding domain, ferredoxin reductase-type
      IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
      IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
      IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
      IPR001834 NADH:cytochrome b5 reductase-like
      IPR001433 Oxidoreductase FAD/NAD(P)-binding
      IPR017938 Riboflavin synthase-like beta-barrel
    Molecular
    Reagents
    less
    • All nucleic 239
      cDNA 237
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-8844, MGD-MRK-8846, MGI:1919569, MGI:1924141, MGI:2146303
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 35
    • Earliest
      J:6442 Taggart RT, et al., Assignment of the gene for NADH diaphorase Dia-1 to Mouse chromosome 15. Somatic Cell Genet. 1980 Nov;6(6):769-76
    • Latest
      J:345057 Im JY, et al., CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1alpha-JNK pathways. Exp Mol Med. 2024 Feb;56(1):235-249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory