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Mylk Gene Detail
Summary
  • Symbol
    Mylk
  • Name
    myosin, light polypeptide kinase
  • Synonyms
    9530072E15Rik, A930019C19Rik, Mlck, MLCK108, MLCK210, nmMlck, telokin
  • Feature Type
    protein coding gene
  • IDs
    MGI:894806
    NCBI Gene: 107589
  • Alliance
  • Transcription Start Sites
    46 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:34565580-34822790 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1797 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894806
protein coding gene Chr16:34565569-34822806 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022764
protein coding gene Chr16:33033768-33289305 (+)
A/J MGP_AJ_G0022729
protein coding gene Chr16:31421858-31677349 (+)
AKR/J MGP_AKRJ_G0022702
protein coding gene Chr16:32531122-32789738 (+)
BALB/cJ MGP_BALBcJ_G0022731
protein coding gene Chr16:31546724-31806719 (+)
C3H/HeJ MGP_C3HHeJ_G0022496
protein coding gene Chr16:32664639-32927145 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023180
protein coding gene Chr16:33737052-34007158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020698
protein coding gene Chr16:31776090-32029381 (+)
CAST/EiJ MGP_CASTEiJ_G0022024
protein coding gene Chr16:32868473-33130074 (+)
CBA/J MGP_CBAJ_G0022466
protein coding gene Chr16:35114658-35388200 (+)
DBA/2J MGP_DBA2J_G0022599
protein coding gene Chr16:31252584-31504682 (+)
FVB/NJ MGP_FVBNJ_G0022574
protein coding gene Chr16:31244578-31517472 (+)
LP/J MGP_LPJ_G0022666
protein coding gene Chr16:32735035-33000805 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022593
protein coding gene Chr16:34438063-34704362 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023192
protein coding gene Chr16:32562407-32824311 (+)
PWK/PhJ MGP_PWKPhJ_G0021765
protein coding gene Chr16:31639514-31896107 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021596
protein coding gene Chr16:32372301-32640241 (+)
WSB/EiJ MGP_WSBEiJ_G0022068
protein coding gene Chr16:32514177-32772960 (+)



Homology
more
  • Human Ortholog
    MYLK, myosin light chain kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYLK, myosin light chain kinase
  • Synonyms
    AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MMIHS, MMIHS1, MSTP083, MYLK1, MYLK-L, smMLCK
  • Links
    NCBI Gene ID: 4638
    neXtProt AC: NX_Q15746
    UniProt: Q15746

  • Chr Location
    3q21.1; chr3:123610049-123884332 (-)  GRCh38

Human Diseases
more
  • Diseases
    5 with human MYLK associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that lack the isoform abundant in endothelial cells show a reduced susceptibility to acute lung injury. Mice lacking the smooth muscle isoform exhibit partial pre- or neonatal lethality, short small intestine and impaired smooth muscle contraction in the colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022836 Ensembl Gene Model | MGI Sequence Detail 257211 C57BL/6J ±  kb
    transcript ENSMUST00000023538 Ensembl | MGI Sequence Detail 7824 Not Applicable  
    polypeptide ENSMUSP00000023538 Ensembl | MGI Sequence Detail 1950 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915492, MGI:2142787, MGI:2443108
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 24
      Gene Ontology 10
      Phenotypes 47
    • Earliest
      J:30019 Gallagher PJ, et al., Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J Biol Chem. 1995 Dec 8;270(49):29090-5
    • Latest
      J:346548 Drolia R, et al., Listeria adhesion protein orchestrates caveolae-mediated apical junctional remodeling of epithelial barrier for Listeria monocytogenes translocation. mBio. 2024 Mar 13;15(3):e0282123

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    04/09/2024
    MGI 6.23
    The Jackson Laboratory