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Numbl Gene Detail
Summary
  • Symbol
    Numbl
  • Name
    numb-like
  • Synonyms
    nbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894702
    NCBI Gene: 18223
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26957884-26981570 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.86 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894702
 protein coding gene Chr7:26957858-26981570 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031905
 protein coding gene Chr7:25887248-25911899 (+)
A/J MGP_AJ_G0031884
 protein coding gene Chr7:25276527-25303437 (+)
AKR/J MGP_AKRJ_G0031814
 protein coding gene Chr7:25940924-25964619 (+)
BALB/cJ MGP_BALBcJ_G0031889
 protein coding gene Chr7:25496344-25520030 (+)
C3H/HeJ MGP_C3HHeJ_G0031611
 protein coding gene Chr7:26326295-26349592 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032354
 protein coding gene Chr7:26740197-26768853 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029406
 protein coding gene Chr7:26511171-26534777 (+)
CAST/EiJ MGP_CASTEiJ_G0030946
 protein coding gene Chr7:19625737-19649314 (+)
CBA/J MGP_CBAJ_G0031576
 protein coding gene Chr7:27920531-27947722 (+)
DBA/2J MGP_DBA2J_G0031728
 protein coding gene Chr7:25073933-25098791 (+)
FVB/NJ MGP_FVBNJ_G0031684
 protein coding gene Chr7:25159076-25186050 (+)
LP/J MGP_LPJ_G0031808
 protein coding gene Chr7:26225295-26248723 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031719
 protein coding gene Chr7:27518629-27543613 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032385
 protein coding gene Chr7:25475826-25503536 (+)
PWK/PhJ MGP_PWKPhJ_G0030670
 protein coding gene Chr7:20107517-20133386 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030504
 protein coding gene Chr7:16464738-16489488 (+)
WSB/EiJ MGP_WSBEiJ_G0031054
 protein coding gene Chr7:25766725-25792209 (+)



Homology
more
  • Human Ortholog
    NUMBL, NUMB like endocytic adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUMBL, NUMB like endocytic adaptor protein
  • Synonyms
    CAG3A, CTG3a, NBL, NUMBLIKE, NUMBR, NUMB-R, TNRC23
  • Links
    NCBI Gene ID: 9253
    neXtProt AC: NX_Q9Y6R0
    UniProt: Q9Y6R0

  • Chr Location
    19q13.2; chr19:40665905-40690972 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    35 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit no overt phenotypes except for a reduction in female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    68
  • cDNA Data
    39
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18223 NCBI Gene Model | MGI Sequence Detail 23687 C57BL/6J ±  kb
    transcript NM_001417032 RefSeq | MGI Sequence Detail 2807 C57BL/6  
    polypeptide O08919 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 2
      cDNA 41
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 39
    • Earliest
      J:41027 Zhong W, et al., Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development. 1997 May;124(10):1887-97
    • Latest
      J:330576 Lacomme M, et al., Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models. Sci Adv. 2022 Oct 21;8(42):eabm4295
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory