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Galnt2 Gene Detail
Summary
  • Symbol
    Galnt2
  • Name
    polypeptide N-acetylgalactosaminyltransferase 2
  • Synonyms
    ppGaNTase-T2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894694
    NCBI Gene: 108148
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124958133-125072461 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.52 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3678 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894694
 protein coding gene Chr8:124958130-125072463 (+)
129S1/SvImJ ENSMUSG00200040974
 protein coding gene Chr8:119204717-119318889 (+)
A/J ENSMUSG00195023975
 protein coding gene Chr8:119495531-119611074 (+)
AKR/J ENSMUSG00220040540
 protein coding gene Chr8:119673291-119787736 (+)
BALB/cJ ENSMUSG00180025095
 protein coding gene Chr8:119540403-119655952 (+)
C3H/HeJ ENSMUSG00175025848
 protein coding gene Chr8:119592748-119707186 (+)
C57BL/6NJ ENSMUSG00215026424
 protein coding gene Chr8:119189937-119304270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031703
 protein coding gene Chr8:115381013-115498986 (+)
CAST/EiJ ENSTCUG00005029891
 protein coding gene Chr8:118948228-119063325 (+)
CBA/J ENSMUSG00210033913
 protein coding gene Chr8:119515957-119630287 (+)
DBA/2J ENSMUSG00185036642
 protein coding gene Chr8:125834878-125949207 (+)
FVB/NJ ENSMUSG00205030995
 protein coding gene Chr8:118486572-118601142 (+)
JF1/MsJ ENSUMUG00000028730
 protein coding gene Chr8:128047928-128163491 (+)
LP/J ENSMUSG00230029679
 protein coding gene Chr8:129387410-129501573 (+)
NOD/ShiLtJ ENSMUSG00190020169
 protein coding gene Chr8:119638411-119752754 (+)
NZO/HlLtJ ENSMUSG00225019713
 protein coding gene Chr8:132756771-132872833 (+)
PWK/PhJ ENSLUMG00010035345
 protein coding gene Chr8:119335725-119451326 (+)
SPRET/EiJ ENSMSPG00010037927
 protein coding gene Chr8:121530407-121645786 (+)
WSB/EiJ ENSIUOG00005026871
 protein coding gene Chr8:120310888-120425403 (+)



Homology
more
  • Human Ortholog
    GALNT2, polypeptide N-acetylgalactosaminyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALNT2, polypeptide N-acetylgalactosaminyltransferase 2
  • Synonyms
    CDG2T, GalNAc-T2
  • Links
    NCBI Gene ID: 2590
    UniProt: Q10471

  • Chr Location
    1q42.13; chr1:230057789-230282128 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GALNT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating HDL cholesterol levels under both chow- and Western diet-fed conditions, a marked elevation in fasting triglyceride levels, and delayed postprandial triglyceride clearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    31
  • cDNA Data
    180
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108148 NCBI Gene Model | MGI Sequence Detail 114329 C57BL/6J ±  kb
    transcript NM_139272 RefSeq | MGI Sequence Detail 4131 Not Specified  
    polypeptide Q6PB93 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      cDNA 180
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142569
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:40489 Hagen FK, et al., cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1997 May 23;272(21):13843-8
    • Latest
      J:360759 Mercanoglu B, et al., GalNT2-mediated O-glycosylation affects pancreas development and function in mice. Sci Rep. 2024 Nov 30;14(1):29760
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory