About   Help   FAQ
Ebf2 Gene Detail
Summary
  • Symbol
    Ebf2
  • Name
    early B cell factor 2
  • Synonyms
    D14Ggc1e, Mmot1, O/E-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:894332
    NCBI Gene: 13592
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67470741-67668367 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.63 cM, cytoband D-E1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4575 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894332
 protein coding gene Chr14:67470741-67668401 (+)
129S1/SvImJ ENSMUSG00200025758
 protein coding gene Chr14:56086892-56285085 (+)
A/J ENSMUSG00195014036
 protein coding gene Chr14:56252527-56450055 (+)
AKR/J ENSMUSG00220026974
 protein coding gene Chr14:55593180-55790684 (+)
BALB/cJ ENSMUSG00180035170
 protein coding gene Chr14:55868704-56066224 (+)
C3H/HeJ ENSMUSG00175037203
 protein coding gene Chr14:57623383-57821593 (+)
C57BL/6NJ ENSMUSG00215020658
 protein coding gene Chr14:55805994-56003643 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019447
 protein coding gene Chr14:58375521-58576239 (+)
CAST/EiJ ENSTCUG00005035568
 protein coding gene Chr14:57513142-57712328 (+)
CBA/J ENSMUSG00210032752
 protein coding gene Chr14:56241244-56438734 (+)
DBA/2J ENSMUSG00185021909
 protein coding gene Chr14:61421185-61619381 (+)
FVB/NJ ENSMUSG00205033787
 protein coding gene Chr14:55755352-55952869 (+)
JF1/MsJ ENSUMUG00000032164
 protein coding gene Chr14:72581873-72780747 (+)
LP/J ENSMUSG00230015321
 protein coding gene Chr14:73450371-73648546 (+)
NOD/ShiLtJ ENSMUSG00190034752
 protein coding gene Chr14:56034433-56231945 (+)
NZO/HlLtJ ENSMUSG00225039800
 protein coding gene Chr14:63767313-63964788 (+)
PWK/PhJ ENSLUMG00010034488
 protein coding gene Chr14:55465693-55664835 (+)
SPRET/EiJ ENSMSPG00010029447
 protein coding gene Chr14:58973800-59172602 (+)
WSB/EiJ ENSIUOG00005034949
 protein coding gene Chr14:55478612-55683995 (+)



Homology
more
  • Human Ortholog
    EBF2, EBF transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EBF2, EBF transcription factor 2
  • Synonyms
    COE2, EBF-2, O/E-3, OE-3
  • Links
    NCBI Gene ID: 64641
    UniProt: Q9HAK2

  • Chr Location
    8p21.2; chr8:25841725-26045413 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 9 alleles in 10 genetic backgrounds
    4 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    288
  • cDNA Data
    47
  • Literature Summary
    74
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022053 Ensembl Gene Model | MGI Sequence Detail 197627 C57BL/6J ±  kb
    transcript ENSMUST00000176029 Ensembl | MGI Sequence Detail 2784 Not Applicable  
    polypeptide ENSMUSP00000135782 Ensembl | MGI Sequence Detail 575 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 49
      Primer pair 6
      Other 6
      Antibodies 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34015, MGI:106323, MGI:894328
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 74
      Gene Ontology 9
      Phenotypes 34
    • Earliest
      J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
    • Latest
      J:381358 Brent AE, et al., SOX9 is part of a combinatorial marker that reveals early development and embryological origins of the mouse brown adipose tissue depots. Dev Biol. 2026 Feb 18;534:23-37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory