P4ha2 MGI Mouse Gene Detail - MGI:894286 - procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide

Symbol

P4ha2
Name

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
Synonyms

P4hl

Feature Type

protein coding gene
IDs

MGI:894286
NCBI Gene: 18452
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:53991750-54022494 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM, cytoband A5-B1
Mapping Data

6 experiments

SNPs within 2kb

833 from dbSNP Build 142
Strain Annotations

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894286	protein coding gene	Chr11:53990921-54022494 (+)
129S1/SvImJ	ENSMUSG00200039125	protein coding gene	Chr11:50987028-51018599 (+)
A/J	ENSMUSG00195030061	protein coding gene	Chr11:50930590-50938519 (+)
AKR/J	ENSMUSG00220035983	protein coding gene	Chr11:51119472-51127401 (+)
BALB/cJ	ENSMUSG00180030776	protein coding gene	Chr11:50995675-51003604 (+)
C3H/HeJ	ENSMUSG00175032965	protein coding gene	Chr11:50961836-50969765 (+)
C57BL/6NJ	ENSMUSG00215022163	protein coding gene	Chr11:50784624-50792553 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016353	protein coding gene	Chr11:49028476-49059655 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210028415	protein coding gene	Chr11:50817712-50825641 (+)
DBA/2J	no annotation
FVB/NJ	ENSMUSG00205021126	protein coding gene	Chr11:50860160-50868089 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230045485	protein coding gene	Chr11:52210883-52218812 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	ENSMUSG00225032132	protein coding gene	Chr11:54257926-54288976 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010017171	protein coding gene	Chr11:51533295-51564635 (+)
WSB/EiJ	no annotation

Human Ortholog

P4HA2, prolyl 4-hydroxylase subunit alpha 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P4HA2, prolyl 4-hydroxylase subunit alpha 2
Synonyms

lncRNA-PE, MYP25
Links

HGNC:8547

NCBI Gene ID: 8974

UniProt: O15460
Chr Location

5q31.1; chr5:132190094-132295315 (-) GRCh38

MGI Vertebrate Homology

P4ha2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: P4HA2
Gene Tree

P4ha2

Diseases

1 with human P4HA2 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

1
Targeted

6
Genomic Mutations

2 involving P4ha2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

868
Tissues

153
cDNA Data

70
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase p4ha2

ZFIN p4ha2

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All Sequences

72
RefSeq

6
UniProt

12
CCDS

CCDS24691.1, CCDS48797.1

Ensembl

ENSMUSG00000018906 (Evidence)
NCBI Gene

18452

			Length	Strain/Species	Flank
genomic	18452	NCBI Gene Model \| MGI Sequence Detail	30745	C57BL/6J	± kb
transcript	NM_011031	RefSeq \| MGI Sequence Detail	2284	C57BL/6
polypeptide	Q60716	UniProt \| EBI \| MGI Sequence Detail	537	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000012197 prolyl 4-hydroxylase subunit alpha-2

(term hierarchy)
EC

1.14.11.2
InterPro Domains

IPR005123 Oxoglutarate/iron-dependent dioxygenase domain

IPR045054 Prolyl 4-hydroxylase

IPR006620 Prolyl 4-hydroxylase, alpha subunit

IPR044862 Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain

IPR013547 Prolyl 4-hydroxylase, N-terminal

IPR059068 Prolyl 4-hydroxylase, peptide-substrate-binding domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat
GlyGen

Q60716 2 sites, 2 N-linked glycans (1 site)

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All nucleic 79

Genomic 3

cDNA 71

Primer pair 4

Other 1

Microarray probesets 3

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MGI:2143965, MGI:2144619

Summaries

All 61

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:386957 Karjalainen E, et al., P4HA3 is dispensable for prolyl 4-hydroxylation of type I collagen during mouse development. J Biol Chem. 2026 Apr 16;302(6):111459

TSS for P4ha2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101468	Chr11:53991795-53991851 (+)	73 bp
Tssr101469	Chr11:53991860-53991869 (+)	115 bp
Tssr101470	Chr11:53992054-53992101 (+)	328 bp
Tssr101471	Chr11:53992407-53992416 (+)	662 bp
Tssr101472	Chr11:54015242-54015246 (+)	23,494 bp
Tssr101473	Chr11:54015332-54015346 (+)	23,589 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24