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Cyp2b9 Gene Detail
Summary
  • Symbol
    Cyp2b9
  • Name
    cytochrome P450, family 2, subfamily b, polypeptide 9
  • Synonyms
    Cyp2b, phenobarbitol inducible, type a
  • Feature Type
    protein coding gene
  • IDs
    MGI:88600
    NCBI Gene: 13094
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25872836-25910086 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.11 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88600
 protein coding gene Chr7:25872775-25910086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031883
 protein coding gene Chr7:24484283-24736691 (+)
A/J MGP_AJ_G0031862
 protein coding gene Chr7:24077882-24114097 (+)
AKR/J MGP_AKRJ_G0031791
 protein coding gene Chr7:24697656-24734866 (+)
BALB/cJ MGP_BALBcJ_G0031867
 protein coding gene Chr7:24292603-24334211 (+)
C3H/HeJ MGP_C3HHeJ_G0031588
 protein coding gene Chr7:25131177-25157483 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032330
 protein coding gene Chr7:25518100-25551755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029385
 protein coding gene Chr7:25166847-25208134 (+)
CAST/EiJ MGP_CASTEiJ_G0030927
 protein coding gene Chr7:18445333-18474673 (+)
CBA/J MGP_CBAJ_G0031553
 protein coding gene Chr7:26481240-26525064 (+)
DBA/2J MGP_DBA2J_G0031707
 protein coding gene Chr7:23724340-24001957 (+)
FVB/NJ MGP_FVBNJ_G0031660
 protein coding gene Chr7:24033209-24074331 (+)
LP/J MGP_LPJ_G0031786
 protein coding gene Chr7:24764175-25029622 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031696
 protein coding gene Chr7:25932815-26223620 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032363
 protein coding gene Chr7:24331595-24360875 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031031
 protein coding gene Chr7:24312740-24609959 (+)



Homology
more
  • Human Ortholog
    CYP2B6, cytochrome P450 family 2 subfamily B member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2B6, cytochrome P450 family 2 subfamily B member 6
  • Synonyms
    CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450
  • Links
    NCBI Gene ID: 1555
    neXtProt AC: NX_P20813
    UniProt: P20813

  • Chr Location
    19q13.2; chr19:40991282-41018398 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human CYP2B6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    1
  • cDNA Data
    25
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040660 Ensembl Gene Model | MGI Sequence Detail 37251 C57BL/6J ±  kb
    transcript ENSMUST00000082214 Ensembl | MGI Sequence Detail 1876 Not Applicable  
    polypeptide ENSMUSP00000080846 Ensembl | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 7
      cDNA 27
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2315, MGD-MRK-2318
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:9563 Noshiro M, et al., Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry. 1988 Aug 23;27(17):6434-43
    • Latest
      J:308780 AlOgayil N, et al., Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver. Sci Rep. 2021 Jul 2;11(1):13766
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory