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Csk Gene Detail
Summary
  • Symbol
    Csk
  • Name
    c-src tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88537
    NCBI Gene: 12988
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57533929-57560758 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.18 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    607 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88537
 protein coding gene Chr9:57533929-57560914 (-)
129S1/SvImJ ENSMUSG00200034714
 protein coding gene Chr9:54659515-54686537 (-)
A/J ENSMUSG00195039305
 protein coding gene Chr9:54359696-54386730 (-)
AKR/J ENSMUSG00220028484
 protein coding gene Chr9:54500531-54527558 (-)
BALB/cJ ENSMUSG00180016434
 protein coding gene Chr9:54473254-54500250 (-)
C3H/HeJ ENSMUSG00175021918
 protein coding gene Chr9:54486498-54513541 (-)
C57BL/6NJ ENSMUSG00215019820
 protein coding gene Chr9:54466617-54493608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032277
 protein coding gene Chr9:54316204-54336806 (-)
CAST/EiJ ENSTCUG00005018763
 protein coding gene Chr9:54390397-54417523 (-)
CBA/J ENSMUSG00210039946
 protein coding gene Chr9:54594743-54621777 (-)
DBA/2J ENSMUSG00185040663
 protein coding gene Chr9:54617028-54644062 (-)
FVB/NJ ENSMUSG00205040067
 protein coding gene Chr9:54923803-54950843 (-)
JF1/MsJ ENSUMUG00000026125
 protein coding gene Chr9:54633703-54660730 (-)
LP/J ENSMUSG00230036182
 protein coding gene Chr9:54859292-54886317 (-)
NOD/ShiLtJ ENSMUSG00190042562
 protein coding gene Chr9:54685028-54712060 (-)
NZO/HlLtJ ENSMUSG00225027410
 protein coding gene Chr9:54898067-54925101 (-)
PWK/PhJ ENSLUMG00010038817
 protein coding gene Chr9:54588938-54615915 (-)
SPRET/EiJ ENSMSPG00010023920
 protein coding gene Chr9:55639198-55664197 (-)
WSB/EiJ ENSIUOG00005034689
 protein coding gene Chr9:54098885-54125142 (-)



Homology
more
  • Human Ortholog
    CSK, C-terminal Src kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSK, C-terminal Src kinase
  • Links
    NCBI Gene ID: 1445
    UniProt: P41240

  • Chr Location
    15q24.1; chr15:74782055-74803198 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 6 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    76
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    53
  • cDNA Data
    133
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12988 NCBI Gene Model | MGI Sequence Detail 26830 C57BL/6J ±  kb
    transcript NM_001411643 RefSeq | MGI Sequence Detail 2808 C57BL/6  
    polypeptide P41241 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 1
      cDNA 135
      Primer pair 4
      Other 2
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2195, MGI:2143301
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 17
      Gene Ontology 16
      Phenotypes 43
    • Earliest
      J:1184 Armstrong E, et al., The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. Cytogenet Cell Genet. 1992;60(2):119-20
    • Latest
      J:376264 Nishimura YV, et al., Csk-dependent and -independent control of Src family kinases directs neuronal migration in the developing cerebral cortex. J Biol Chem. 2025 Oct 30;301(12):110877
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory