Cp MGI Mouse Gene Detail - MGI:88476

Symbol

Cp
Name

ceruloplasmin
Synonyms

D3Ertd555e

Feature Type

protein coding gene
IDs

MGI:88476
NCBI Gene: 12870
Alliance

genome feature page
Transcription Start Sites

25 TSS

Sequence Map

Chr3:20011218-20063309 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 6.10 cM, cytoband D
Mapping Data

8 experiments

SNPs within 2kb

1761 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88476	protein coding gene	Chr3:20011097-20063914 (+)
129S1/SvImJ	ENSMUSG00200018161	protein coding gene	Chr3:16789557-16838079 (+)
A/J	ENSMUSG00195015322	protein coding gene	Chr3:16841833-16890366 (+)
AKR/J	ENSMUSG00220008816	protein coding gene	Chr3:16802206-16850724 (+)
BALB/cJ	ENSMUSG00180000958	protein coding gene	Chr3:16863501-16912022 (+)
C3H/HeJ	ENSMUSG00175003062	protein coding gene	Chr3:16861804-16910337 (+)
C57BL/6NJ	ENSMUSG00215001220	protein coding gene	Chr3:17071724-17120253 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024876	protein coding gene	Chr3:15149996-15201795 (+)
CAST/EiJ	ENSTCUG00005023821	protein coding gene	Chr3:16791928-16840140 (+)
CBA/J	ENSMUSG00210001480	protein coding gene	Chr3:16837103-16885632 (+)
DBA/2J	ENSMUSG00185000614	protein coding gene	Chr3:17055514-17104033 (+)
FVB/NJ	ENSMUSG00205002449	protein coding gene	Chr3:16358416-16406943 (+)
JF1/MsJ	ENSUMUG00000014140	protein coding gene	Chr3:16655354-16704722 (+)
LP/J	ENSMUSG00230004085	protein coding gene	Chr3:18961235-19009749 (+)
NOD/ShiLtJ	ENSMUSG00190001681	protein coding gene	Chr3:17217508-17266025 (+)
NZO/HlLtJ	ENSMUSG00225006812	protein coding gene	Chr3:21607256-21655770 (+)
PWK/PhJ	ENSLUMG00010002965	protein coding gene	Chr3:16677900-16726316 (+)
SPRET/EiJ	ENSMSPG00010001819	protein coding gene	Chr3:16797775-16846990 (+)
WSB/EiJ	ENSIUOG00005001239	protein coding gene	Chr3:17098446-17147276 (+)

Human Ortholog

CP, ceruloplasmin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CP, ceruloplasmin
Synonyms

AB073614, CP-2
Links

HGNC:2295

NCBI Gene ID: 1356

UniProt: P00450
Chr Location

3q24-q25.1; chr3:149162410-149221998 (-) GRCh38

MGI Vertebrate Homology

Cp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CP
Protein SuperFamily

Factors_V_VIII
Gene Tree

Cp

Diseases

1 with Cp mouse models; 3 with human CP associations

Human Disease

Mouse Models

aceruloplasminemia

IDs

View 3 models

epilepsy

IDs

hemosiderosis

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

6 with disease annotations

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Phenotype Summary

41 phenotypes from 6 alleles in 7 genetic backgrounds
22 phenotypes from multigenic genotypes
4 images
66 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Endonuclease-mediated

8
Radiation induced

1
Spontaneous

2
Targeted

6
Genomic Mutations

1 involving Cp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.

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All GO Annotations

58
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

922
Tissues

188
cDNA Data

386
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cp

ZFIN cp

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All Sequences

94
RefSeq

22
UniProt

11
CCDS

CCDS38400.1, CCDS38401.1, CCDS71227.1, CCDS89616.1

Ensembl

ENSMUSG00000003617 (Evidence)
NCBI Gene

12870

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003617	Ensembl Gene Model \| MGI Sequence Detail	52092	C57BL/6J	± kb
transcript	ENSMUST00000108329	Ensembl \| MGI Sequence Detail	4564	Not Applicable
polypeptide	ENSMUSP00000103965	Ensembl \| MGI Sequence Detail	1086	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000005794 ceruloplasmin

(term hierarchy)
EC

1.11.1.27, 1.11.1.9, 1.16.3.1, 1.16.3.4
InterPro Domains

IPR048236 Ceruloplasmin-like, fifth cupredoxin domain

IPR024715 Coagulation factor 5/8-like

IPR008972 Cupredoxin

IPR045087 Multicopper oxidase

IPR002355 Multicopper oxidase, copper-binding site

IPR011706 Multicopper oxidase-like, C-terminal

IPR011707 Multicopper oxidase-like, N-terminal

IPR033138 Multicopper oxidases, conserved site

IPR001117 Multicopper oxidase, second cupredoxin domain
GlyGen

Q61147 7 sites, 6 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 394

Genomic 3

cDNA 387

Primer pair 4

Antibodies 2

Microarray probesets 10

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MGD-MRK-2100, MGI:1261828

Summaries

All 122

Developmental Gene Expression 12

Diseases 6

Gene Ontology 17

Phenotypes 66
Earliest

J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
Latest

J:377271 Kedari KG, et al., Astrocyte-specific deletion of ceruloplasmin exacerbates oxidative stress and demyelination in the spinal cord in a murine model of multiple sclerosis. Neurobiol Dis. 2025 Dec 25;:107249

TSS for Cp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28534	Chr3:20011089-20011094 (+)	-126 bp
Tssr28535	Chr3:20011150-20011157 (+)	-64 bp
Tssr28536	Chr3:20011201-20011237 (+)	1 bp
Tssr28537	Chr3:20011252-20011278 (+)	47 bp
Tssr28538	Chr3:20011283-20011295 (+)	71 bp
Tssr28539	Chr3:20011334-20011343 (+)	121 bp
Tssr28540	Chr3:20011379-20011388 (+)	166 bp
Tssr28541	Chr3:20011404-20011427 (+)	198 bp
Tssr28542	Chr3:20011505-20011520 (+)	295 bp
Tssr28543	Chr3:20020509-20020520 (+)	9,297 bp
Tssr28544	Chr3:20020527-20020547 (+)	9,319 bp
Tssr28545	Chr3:20025079-20025088 (+)	13,866 bp
Tssr28546	Chr3:20025176-20025193 (+)	13,967 bp
Tssr28547	Chr3:20026789-20026800 (+)	15,577 bp
Tssr28548	Chr3:20029130-20029143 (+)	17,919 bp
Tssr28549	Chr3:20034753-20034762 (+)	23,540 bp
Tssr839	Chr3:20039775-20039787 (+)	28,563 bp
Tssr28550	Chr3:20039796-20039807 (+)	28,584 bp
Tssr28551	Chr3:20043219-20043233 (+)	32,008 bp
Tssr28552	Chr3:20043298-20043313 (+)	32,088 bp
Tssr28553	Chr3:20043315-20043328 (+)	32,104 bp
Tssr28554	Chr3:20043340-20043355 (+)	32,130 bp
Tssr28555	Chr3:20046787-20046803 (+)	35,577 bp
Tssr28556	Chr3:20046939-20046957 (+)	35,730 bp
Tssr840	Chr3:20046960-20046981 (+)	35,753 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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