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Cox5a Gene Detail
Summary
  • Symbol
    Cox5a
  • Name
    cytochrome c oxidase subunit 5A
  • Synonyms
    CcOX
  • Feature Type
    protein coding gene
  • IDs
    MGI:88474
    NCBI Gene: 12858
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57428557-57439709 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.05 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88474
 protein coding gene Chr9:57423012-57439710 (+)
129S1/SvImJ ENSMUSG00200034121
 protein coding gene Chr9:54553879-54566120 (+)
A/J ENSMUSG00195036431
 protein coding gene Chr9:54254005-54266247 (+)
AKR/J ENSMUSG00220027871
 protein coding gene Chr9:54394819-54407049 (+)
BALB/cJ ENSMUSG00180016056
 protein coding gene Chr9:54367638-54379887 (+)
C3H/HeJ ENSMUSG00175021563
 protein coding gene Chr9:54380808-54393050 (+)
C57BL/6NJ ENSMUSG00215016083
 protein coding gene Chr9:54360994-54373251 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032270
 protein coding gene Chr9:54212315-54222813 (+)
CAST/EiJ ENSTCUG00005018182
 protein coding gene Chr9:54284718-54296911 (+)
CBA/J ENSMUSG00210035133
 protein coding gene Chr9:54489041-54501289 (+)
DBA/2J ENSMUSG00185042737
 protein coding gene Chr9:54511255-54523511 (+)
FVB/NJ ENSMUSG00205032381
 protein coding gene Chr9:54818012-54830273 (+)
JF1/MsJ ENSUMUG00000022642
 protein coding gene Chr9:54527858-54540102 (+)
LP/J ENSMUSG00230038936
 protein coding gene Chr9:54753651-54765891 (+)
NOD/ShiLtJ ENSMUSG00190034179
 protein coding gene Chr9:54579261-54591529 (+)
NZO/HlLtJ ENSMUSG00225027529
 protein coding gene Chr9:54792389-54804633 (+)
PWK/PhJ ENSLUMG00010035654
 protein coding gene Chr9:54482522-54495428 (+)
SPRET/EiJ ENSMSPG00010022505
 protein coding gene Chr9:55528840-55539314 (+)
WSB/EiJ ENSIUOG00005033660
 protein coding gene Chr9:53993223-54005468 (+)



Homology
more
  • Human Ortholog
    COX5A, cytochrome c oxidase subunit 5A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX5A, cytochrome c oxidase subunit 5A
  • Synonyms
    COX, COX-VA, MC4DN20, VA
  • Links
    NCBI Gene ID: 9377
    UniProt: P20674

  • Chr Location
    15q24.2; chr15:74919791-74939351 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COX5A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    111
  • cDNA Data
    351
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000088 Ensembl Gene Model | MGI Sequence Detail 11153 C57BL/6J ±  kb
transcript ENSMUST00000000090 Ensembl | MGI Sequence Detail 645 Not Applicable  
polypeptide ENSMUSP00000000090 Ensembl | MGI Sequence Detail 146 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 358
    cDNA 354
    Primer pair 4
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2098, MGI:2144051
References
more
  • Summaries
    All 74
    Developmental Gene Expression 9
    Gene Ontology 18
    Phenotypes 9
  • Earliest
    J:20269 Wright RM, et al., Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae. J Biol Chem. 1984 Dec 25;259(24):15401-7
  • Latest
    J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory