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Capns1 Gene Detail
Summary
  • Symbol
    Capns1
  • Name
    calpain, small subunit 1
  • Synonyms
    Capa4, Capa-4, Capn4, D7Ertd146e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88266
    NCBI Gene: 12336
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:29886361-29898236 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    198 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88266
 protein coding gene Chr7:29886359-29898308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032005
 protein coding gene Chr7:29162867-29170881 (-)
A/J MGP_AJ_G0031982
 protein coding gene Chr7:28397401-28405428 (-)
AKR/J MGP_AKRJ_G0031915
 protein coding gene Chr7:29125645-29133665 (-)
BALB/cJ MGP_BALBcJ_G0031989
 protein coding gene Chr7:28572859-28581150 (-)
C3H/HeJ MGP_C3HHeJ_G0031708
 protein coding gene Chr7:29562197-29570099 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032454
 protein coding gene Chr7:30097010-30107134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029505
 protein coding gene Chr7:29432546-29440343 (-)
CAST/EiJ MGP_CASTEiJ_G0031042
 protein coding gene Chr7:22811230-22821043 (-)
CBA/J MGP_CBAJ_G0031674
 protein coding gene Chr7:31551071-31564272 (-)
DBA/2J MGP_DBA2J_G0031826
 protein coding gene Chr7:28126332-28134305 (-)
FVB/NJ MGP_FVBNJ_G0031783
 protein coding gene Chr7:28238636-28247292 (-)
LP/J MGP_LPJ_G0031907
 protein coding gene Chr7:29486992-29494867 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031819
 protein coding gene Chr7:30818806-30829667 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032483
 protein coding gene Chr7:28615745-28626628 (-)
PWK/PhJ MGP_PWKPhJ_G0030767
 protein coding gene Chr7:23143955-23165115 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030601
 protein coding gene Chr7:19613456-19624403 (-)
WSB/EiJ MGP_WSBEiJ_G0031152
 protein coding gene Chr7:28996867-29009838 (-)



Homology
more
  • Human Ortholog
    CAPNS1, calpain small subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPNS1, calpain small subunit 1
  • Synonyms
    CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, PPH6
  • Links
    NCBI Gene ID: 826
    neXtProt AC: NX_P04632
    UniProt: P04632

  • Chr Location
    19q13.12; chr19:36139953-36150353 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 6 alleles in 5 genetic backgrounds
    2 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E11.5. Mutant embryos exhibit cardiac developmental defects, reduced yolk sac vasculature, hemorrhaging in the area between the embryo and amnion, and accumulation of nucleated erythroid cells in the heart chambers, blood vessels, and developing liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    4
  • cDNA Data
    317
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001794 Ensembl Gene Model | MGI Sequence Detail 11876 C57BL/6J ±  kb
    transcript ENSMUST00000001845 Ensembl | MGI Sequence Detail 1600 Not Applicable  
    polypeptide ENSMUSP00000001845 Ensembl | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 319
      Genomic 1
      cDNA 317
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1753, MGD-MRK-1757, MGI:1098835
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 43
    • Earliest
      J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
    • Latest
      J:340468 Wang Y, et al., Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype. Free Radic Biol Med. 2023 Sep 1;208:430-444
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory