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C2 Gene Detail
Summary
  • Symbol
    C2
  • Name
    complement C2
  • Synonyms
    classical-complement pathway C3/C5 convertase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88226
    NCBI Gene: 12263
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35081578-35101076 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.41 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88226
 protein coding gene Chr17:35081578-35117241 (-)
129S1/SvImJ ENSMUSG00200050619
 protein coding gene Chr17:30784762-30817710 (-)
A/J ENSMUSG00195040552
 protein coding gene Chr17:31684933-31717870 (-)
AKR/J ENSMUSG00220049916
 protein coding gene Chr17:30713609-30746549 (-)
BALB/cJ ENSMUSG00180039103
 protein coding gene Chr17:31054799-31087738 (-)
C3H/HeJ ENSMUSG00175033927
 protein coding gene Chr17:30599723-30632668 (-)
C57BL/6NJ ENSMUSG00215050609
 protein coding gene Chr17:30624949-30657902 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021481
 protein coding gene Chr17:31597500-31634452 (-)
CAST/EiJ ENSTCUG00005048148
 protein coding gene Chr17:31643192-31676433 (-)
CBA/J ENSMUSG00210052048
 protein coding gene Chr17:30421830-30454775 (-)
DBA/2J ENSMUSG00185050802
 protein coding gene Chr17:33074063-33106995 (-)
FVB/NJ ENSMUSG00205051832
 protein coding gene Chr17:30943489-30976491 (-)
JF1/MsJ ENSUMUG00000056903
 protein coding gene Chr17:32326590-32359839 (-)
LP/J ENSMUSG00230054618
 protein coding gene Chr17:34183024-34215967 (-)
NOD/ShiLtJ ENSMUSG00190051592
 protein coding gene Chr17:30544536-30577516 (-)
NZO/HlLtJ ENSMUSG00225054003
 protein coding gene Chr17:36196016-36229117 (-)
PWK/PhJ ENSLUMG00010038107
 protein coding gene Chr17:30161477-30194366 (-)
SPRET/EiJ ENSMSPG00010048115
 protein coding gene Chr17:31347095-31381082 (-)
WSB/EiJ ENSIUOG00005051160
 protein coding gene Chr17:31272277-31305076 (-)



Homology
more
  • Human Ortholog
    C2, complement C2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C2, complement C2
  • Synonyms
    ARMD14, CO2
  • Links
    NCBI Gene ID: 717
    UniProt: P06681

  • Chr Location
    6p21.33; chr6:31897783-31945674 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human C2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    123
  • cDNA Data
    41
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12263 NCBI Gene Model | MGI Sequence Detail 19499 C57BL/6J ±  kb
transcript NM_013484 RefSeq | MGI Sequence Detail 2639 C57BL/6  
polypeptide P21180 UniProt | EBI | MGI Sequence Detail 760 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 4
    cDNA 41
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1699
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 5
  • Earliest
    J:6325 Gorman JC, et al., Development of a hemolytic assay for mouse C2 and determination of its genetic control. J Immunol. 1980 Jul;125(1):344-51
  • Latest
    J:369997 Devalaraja-Narashimha K, et al., Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy. J Am Soc Nephrol. 2021 Jan;32(1):99-114
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory