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Bmp3 Gene Detail
Summary
  • Symbol
    Bmp3
  • Name
    bone morphogenetic protein 3
  • Synonyms
    9530029I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88179
    NCBI Gene: 110075
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:99002274-99031912 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.24 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    950 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88179
 protein coding gene Chr5:99002274-99032255 (+)
129S1/SvImJ ENSMUSG00200006021
 protein coding gene Chr5:92725533-92755534 (+)
A/J ENSMUSG00195034778
 protein coding gene Chr5:92285497-92315507 (+)
AKR/J ENSMUSG00220031601
 protein coding gene Chr5:91755067-91785074 (+)
BALB/cJ ENSMUSG00180029643
 protein coding gene Chr5:92441733-92471739 (+)
C3H/HeJ ENSMUSG00175029173
 protein coding gene Chr5:94540026-94570034 (+)
C57BL/6NJ ENSMUSG00215011652
 protein coding gene Chr5:92385605-92415590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027442
 protein coding gene Chr5:91817418-91847432 (+)
CAST/EiJ ENSTCUG00005023210
 protein coding gene Chr5:91792290-91822438 (+)
CBA/J ENSMUSG00210033211
 protein coding gene Chr5:93299083-93329090 (+)
DBA/2J ENSMUSG00185035099
 protein coding gene Chr5:96215102-96245108 (+)
FVB/NJ ENSMUSG00205036745
 protein coding gene Chr5:92199325-92229332 (+)
JF1/MsJ ENSUMUG00000035724
 protein coding gene Chr5:99214334-99244806 (+)
LP/J ENSMUSG00230027901
 protein coding gene Chr5:100278452-100308445 (+)
NOD/ShiLtJ ENSMUSG00190020477
 protein coding gene Chr5:92210829-92240853 (+)
NZO/HlLtJ ENSMUSG00225012907
 protein coding gene Chr5:108030973-108060978 (+)
PWK/PhJ ENSLUMG00010013112
 protein coding gene Chr5:91338203-91368529 (+)
SPRET/EiJ ENSMSPG00010021405
 protein coding gene Chr5:94228725-94267578 (+)
WSB/EiJ ENSIUOG00005029459
 protein coding gene Chr5:94954071-94984150 (+)



Homology
more
  • Human Ortholog
    BMP3, bone morphogenetic protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP3, bone morphogenetic protein 3
  • Synonyms
    BMP-3A
  • Links
    NCBI Gene ID: 651
    UniProt: P12645

  • Chr Location
    4q21.21; chr4:81030632-81057627 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased bone density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1011
  • Tissues
    158
  • cDNA Data
    19
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110075 NCBI Gene Model | MGI Sequence Detail 29639 C57BL/6J ±  kb
    transcript NM_001310677 RefSeq | MGI Sequence Detail 6302 ZRU/MplStud  
    polypeptide Q8BHE5 UniProt | EBI | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 3
      Other 4
      Antibodies 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1601, MGI:2442431
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 38
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:365296 Bottasso-Arias N, et al., Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea. Front Cell Dev Biol. 2025;13:1523833
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory