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Bgn Gene Detail
Summary
  • Symbol
    Bgn
  • Name
    biglycan
  • Synonyms
    BG, SLRR1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:88158
    NCBI Gene: 12111
  • Alliance
    genome feature page
  • Transcription Start Sites
    45 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72527208-72539539 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.33 cM, cytoband B
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88158
 protein coding gene ChrX:72527207-72539542 (+)
129S1/SvImJ ENSMUSG00200042834
 protein coding gene ChrX:54587521-54599966 (+)
A/J ENSMUSG00195031852
 protein coding gene ChrX:58263828-58276237 (+)
AKR/J ENSMUSG00220042009
 protein coding gene ChrX:53566147-53578547 (+)
BALB/cJ ENSMUSG00180049424
 protein coding gene ChrX:54844580-54856983 (+)
C3H/HeJ ENSMUSG00175030453
 protein coding gene ChrX:58428245-58440653 (+)
C57BL/6NJ ENSMUSG00215041422
 protein coding gene ChrX:54928298-54940745 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033151
 protein coding gene ChrX:68489621-68501535 (+)
CAST/EiJ ENSTCUG00005040037
 protein coding gene ChrX:56345264-56357637 (+)
CBA/J ENSMUSG00210035368
 protein coding gene ChrX:55108916-55121320 (+)
DBA/2J ENSMUSG00185030060
 protein coding gene ChrX:67530573-67542982 (+)
FVB/NJ ENSMUSG00205038940
 protein coding gene ChrX:54409883-54422294 (+)
JF1/MsJ ENSUMUG00000021183
 protein coding gene ChrX:88269415-88281809 (+)
LP/J ENSMUSG00230030248
 protein coding gene ChrX:74109699-74122142 (+)
NOD/ShiLtJ ENSMUSG00190029433
 protein coding gene ChrX:54348932-54361339 (+)
NZO/HlLtJ ENSMUSG00225047441
 protein coding gene ChrX:79314048-79326485 (+)
PWK/PhJ ENSLUMG00010040320
 protein coding gene ChrX:54090681-54103018 (+)
SPRET/EiJ ENSMSPG00010029783
 protein coding gene ChrX:57172854-57185158 (+)
WSB/EiJ ENSIUOG00005047475
 protein coding gene ChrX:55173916-55186308 (+)



Homology
more
  • Human Ortholog
    BGN, biglycan
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BGN, biglycan
  • Synonyms
    DSPG1, MRLS, PGI, PG-S1, SEMDX, SLRR1A
  • Links
    NCBI Gene ID: 633
    UniProt: P21810

  • Chr Location
    Xq28; chrX:153488654-153510299 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BGN associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    34 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display reduced growth and develop age-dependent osteopenia. Age-related osteoporosis is associated with defects in bone marrow stromal cells, including increased apoptosis, reduced numbers of colony-forming units-fibroblastic (CFU-F), and decreased collagen production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    157
  • cDNA Data
    328
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031375 Ensembl Gene Model | MGI Sequence Detail 12332 C57BL/6J ±  kb
    transcript ENSMUST00000033741 Ensembl | MGI Sequence Detail 2419 Not Applicable  
    polypeptide ENSMUSP00000033741 Ensembl | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000004735 biglycan
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
      IPR050333 Small Leucine-Rich Proteoglycans
    • GlyGen
      P28653 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 347
      Genomic 9
      cDNA 330
      Primer pair 6
      Other 2
      Antibodies 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1554
    References
    more
    • Summaries
      All 200
      Developmental Gene Expression 46
      Diseases 4
      Gene Ontology 14
      Phenotypes 75
    • Earliest
      J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
    • Latest
      J:370952 Pina JO, et al., Single cell spatial transcriptomics links Wnt signaling disruption to extracellular matrix development in a cleft palate model. Sci Rep. 2025 Aug 13;15(1):29639
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory