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Atp4b Gene Detail
Summary
  • Symbol
    Atp4b
  • Name
    ATPase, H+/K+ exchanging, beta polypeptide
  • Synonyms
    H+,K+-ATPase, H+/K+-ATPase beta, H,K-ATPase-Beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:88114
    NCBI Gene: 11945
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13436209-13446778 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88114
 protein coding gene Chr8:13436205-13446825 (-)
129S1/SvImJ ENSMUSG00200028887
 protein coding gene Chr8:10329819-10340438 (-)
A/J ENSMUSG00195039428
 protein coding gene Chr8:10679416-10690037 (-)
AKR/J ENSMUSG00220029455
 protein coding gene Chr8:10408689-10419310 (-)
BALB/cJ ENSMUSG00180019827
 protein coding gene Chr8:10318539-10329159 (-)
C3H/HeJ ENSMUSG00175033848
 protein coding gene Chr8:10478334-10488954 (-)
C57BL/6NJ ENSMUSG00215014453
 protein coding gene Chr8:10352683-10363303 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030840
 protein coding gene Chr8:9845521-9854038 (-)
CAST/EiJ ENSTCUG00005018083
 protein coding gene Chr8:10329013-10337789 (-)
CBA/J ENSMUSG00210041248
 protein coding gene Chr8:10312180-10322799 (-)
DBA/2J ENSMUSG00185006687
 protein coding gene Chr8:10444910-10455530 (-)
FVB/NJ ENSMUSG00205030924
 protein coding gene Chr8:10337630-10348251 (-)
JF1/MsJ ENSUMUG00000022267
 protein coding gene Chr8:10464788-10473512 (-)
LP/J ENSMUSG00230021712
 protein coding gene Chr8:12623736-12631967 (-)
NOD/ShiLtJ ENSMUSG00190035501
 protein coding gene Chr8:10437003-10447623 (-)
NZO/HlLtJ ENSMUSG00225042012
 protein coding gene Chr8:20489797-20500416 (-)
PWK/PhJ ENSLUMG00010029117
 protein coding gene Chr8:10391757-10400481 (-)
SPRET/EiJ ENSMSPG00010013893
 protein coding gene Chr8:10503717-10512154 (-)
WSB/EiJ ENSIUOG00005019286
 protein coding gene Chr8:10344603-10353364 (-)



Homology
more
  • Human Ortholog
    ATP4B, ATPase H+/K+ transporting subunit beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP4B, ATPase H+/K+ transporting subunit beta
  • Synonyms
    ATP6B
  • Links
    NCBI Gene ID: 496
    UniProt: P51164

  • Chr Location
    13q34; chr13:113648804-113658198 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ATP4B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are superficially normal but have hypertrophied stomach mucosa, neutral luminal pH in the stomach, and hypergastrinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    107
  • cDNA Data
    18
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11945 NCBI Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
    transcript NM_009724 RefSeq | MGI Sequence Detail 1327 ZRU/MplStud  
    polypeptide P50992 UniProt | EBI | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004452 potassium-transporting ATPase subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR000402 Sodium/potassium-transporting ATPase subunit beta
      IPR038702 Sodium/potassium-transporting ATPase subunit beta superfamily
    • GlyGen
      P50992 7 sites
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 6
      cDNA 20
      Primer pair 1
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1467, MGI:2142736
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 31
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:10832 Canfield VA, et al., Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. J Biol Chem. 1990 Nov 15;265(32):19878-84
    • Latest
      J:388802 Mu R, et al., Yap mediates hippo signaling to balance proliferation and differentiation in the developing glandular stomach epithelium. Cell Rep. 2026 Jul 3;45(7):117644
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory