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Atp2b4 Gene Detail
Summary
  • Symbol
    Atp2b4
  • Name
    ATPase, Ca++ transporting, plasma membrane 4
  • Synonyms
    PMCA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88111
    NCBI Gene: 381290
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:133630416-133728755 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2261 from dbSNP Build 142
  • Strain Annotations
    21
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88111
 protein coding gene Chr1:133627195-133728779 (-)
129S1/SvImJ ENSMUSG00200007634
 protein coding gene Chr1:131231204-131332850 (-)
A/J ENSMUSG00195041647
 protein coding gene Chr1:130305692-130407294 (-)
AKR/J ENSMUSG00220046430
 protein coding gene Chr1:130175399-130277024 (-)
BALB/cJ ENSMUSG00180034936
 protein coding gene Chr1:130853817-130955404 (-)
C3H/HeJ ENSMUSG00175044625
 protein coding gene Chr1:130550061-130651644 (-)
C57BL/6NJ ENSMUSG00215044794
 protein coding gene Chr1:130555493-130657093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014608
 protein coding gene Chr1:125307823-125408066 (-)
CAST/EiJ ENSTCUG00005032677
 protein coding gene Chr1:129464251-129567011 (-)
CBA/J ENSMUSG00210026711
 protein coding gene Chr1:130470923-130572473 (-)
DBA/2J ENSMUSG00185030151
 protein coding gene Chr1:134844338-134844592 (-)
DBA/2J ENSMUSG00185030090
 protein coding gene Chr1:134845057-134943786 (-)
FVB/NJ ENSMUSG00205028653
 protein coding gene Chr1:129810332-129908988 (-)
FVB/NJ ENSMUSG00205028943
 protein coding gene Chr1:129809621-129809872 (-)
JF1/MsJ ENSUMUG00000044925
 protein coding gene Chr1:133994235-134093892 (-)
LP/J ENSMUSG00230038681
 protein coding gene Chr1:134388795-134490369 (-)
NOD/ShiLtJ ENSMUSG00190040250
 protein coding gene Chr1:130485128-130586680 (-)
NZO/HlLtJ ENSMUSG00225016677
 protein coding gene Chr1:138141857-138243442 (-)
PWK/PhJ ENSLUMG00010023115
 protein coding gene Chr1:129624042-129722872 (-)
SPRET/EiJ ENSMSPG00010042279
 protein coding gene Chr1:132425731-132471700 (-)
WSB/EiJ ENSIUOG00005045138
 protein coding gene Chr1:130226680-130325778 (-)



Homology
more
  • Human Ortholog
    ATP2B4, ATPase plasma membrane Ca2+ transporting 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP2B4, ATPase plasma membrane Ca2+ transporting 4
  • Synonyms
    ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
  • Links
    NCBI Gene ID: 493
    UniProt: P23634

  • Chr Location
    1q32.1; chr1:203626778-203744081 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility with impaired sperm motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    126
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    112
  • cDNA Data
    45
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381290 NCBI Gene Model | MGI Sequence Detail 98340 C57BL/6J ±  kb
    transcript NM_001421080 RefSeq | MGI Sequence Detail 8633 C57BL/6  
    polypeptide Q6Q477 UniProt | EBI | MGI Sequence Detail 1205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000004448 plasma membrane calcium-transporting ATPase 4
      (term hierarchy)
    • EC
      7.2.2.10
    • InterPro Domains
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal
      IPR001757 P-type ATPase
      IPR059000 P-type ATPase, A domain
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR044492 P-type ATPase, haloacid dehalogenase domain
      IPR018303 P-type ATPase, phosphorylation site
      IPR006408 P-type ATPase, subfamily IIB
      IPR023298 P-type ATPase, transmembrane domain superfamily
    • GlyGen
      Q6Q477 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1464
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 34
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory