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Apoh Gene Detail
Summary
  • Symbol
    Apoh
  • Name
    apolipoprotein H
  • Synonyms
    B2GPI, beta-2-glycoprotein 1, beta-2-GPI
  • Feature Type
    protein coding gene
  • IDs
    MGI:88058
    NCBI Gene: 11818
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:108286123-108305222 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 71.80 cM, cytoband D
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88058
 protein coding gene Chr11:108234180-108305222 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019326
 protein coding gene Chr11:111809497-111881919 (+)
A/J MGP_AJ_G0019294
 protein coding gene Chr11:106998406-107061406 (+)
AKR/J MGP_AKRJ_G0019263
 protein coding gene Chr11:110198911-110270885 (+)
BALB/cJ MGP_BALBcJ_G0019268
 protein coding gene Chr11:107429141-107491317 (+)
C3H/HeJ MGP_C3HHeJ_G0019077
 protein coding gene Chr11:110515287-110582311 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019718
 protein coding gene Chr11:115216087-115290345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017342
 protein coding gene Chr11:104263924-104325373 (+)
CAST/EiJ MGP_CASTEiJ_G0018630
 protein coding gene Chr11:111624519-111694228 (+)
CBA/J MGP_CBAJ_G0019046
 protein coding gene Chr11:119999915-120068398 (+)
DBA/2J MGP_DBA2J_G0019158
 protein coding gene Chr11:106476652-106549239 (+)
FVB/NJ MGP_FVBNJ_G0019149
 protein coding gene Chr11:105983753-106046229 (+)
LP/J MGP_LPJ_G0019228
 protein coding gene Chr11:112240989-112316256 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019179
 protein coding gene Chr11:119180261-119251040 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019755
 protein coding gene Chr11:110764816-110835983 (+)
PWK/PhJ MGP_PWKPhJ_G0018395
 protein coding gene Chr11:107634781-107699132 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018186
 protein coding gene Chr11:110510899-110584402 (+)
WSB/EiJ MGP_WSBEiJ_G0018681
 protein coding gene Chr11:110697628-110767753 (+)



Homology
more
  • Human Ortholog
    APOH, apolipoprotein H
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOH, apolipoprotein H
  • Synonyms
    B2G1, B2GP1, BG
  • Links
    NCBI Gene ID: 350
    neXtProt AC: NX_P02749
    UniProt: P02749

  • Chr Location
    17q24.2; chr17:66212033-66256525 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human APOH associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced viability and reduced thrombin production. Only 8% homozygous null animals are born from heterozygous intercrosses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    10
  • cDNA Data
    187
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11818 NCBI Gene Model | MGI Sequence Detail 19100 C57BL/6J ±  kb
    transcript NM_013475 RefSeq | MGI Sequence Detail 1202 ZRU/MplStud  
    polypeptide Q01339 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 193
      Genomic 1
      cDNA 188
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1377
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:1723 Nonaka M, et al., Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11. Genomics. 1992 Aug;13(4):1082-7
    • Latest
      J:330422 Passam FH, et al., Betaeta-2-glycoprotein I exerts antithrombotic function through its domain V in mice. J Autoimmun. 2022 Jan;126:102747
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory