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Ank2 Gene Detail
Summary
  • Symbol
    Ank2
  • Name
    ankyrin 2, brain
  • Synonyms
    Ank-2, Ankyrin-2, ankyrin B, Ankyrin-B, Gm4392
  • Feature Type
    protein coding gene
  • IDs
    MGI:88025
    NCBI Gene: 109676
  • Alliance
  • Transcription Start Sites
    48 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:126715261-127292999 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 56.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18993 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88025
protein coding gene Chr3:126715256-127293996 (-)
129S1/SvImJ ENSMUSG00200003016
protein coding gene Chr3:123447580-124033741 (-)
A/J ENSMUSG00195007702
protein coding gene Chr3:123587218-124172406 (-)
AKR/J ENSMUSG00220021430
protein coding gene Chr3:122025671-122607329 (-)
BALB/cJ ENSMUSG00180003377
protein coding gene Chr3:123514494-124099581 (-)
C3H/HeJ ENSMUSG00175012684
protein coding gene Chr3:123061025-123653259 (-)
C57BL/6NJ ENSMUSG00215014993
protein coding gene Chr3:123860453-124438314 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025612
protein coding gene Chr3:120210115-120793631 (-)
CAST/EiJ ENSTCUG00005003658
protein coding gene Chr3:124120989-124724156 (-)
CBA/J ENSMUSG00210003447
protein coding gene Chr3:123691424-124276514 (-)
DBA/2J ENSMUSG00185024801
protein coding gene Chr3:124304035-124891143 (-)
FVB/NJ ENSMUSG00205007084
protein coding gene Chr3:122658396-123236317 (-)
JF1/MsJ ENSUMUG00000021889
protein coding gene Chr3:123059296-123644718 (-)
LP/J ENSMUSG00230003142
protein coding gene Chr3:126282080-126866793 (-)
NOD/ShiLtJ ENSMUSG00190001367
protein coding gene Chr3:124710344-125280731 (-)
NZO/HlLtJ ENSMUSG00225001926
protein coding gene Chr3:128748070-129325939 (-)
PWK/PhJ ENSLUMG00010015050
protein coding gene Chr3:123090262-123665744 (-)
SPRET/EiJ ENSMSPG00010012001
protein coding gene Chr3:123977129-124582498 (-)
WSB/EiJ ENSIUOG00005016190
protein coding gene Chr3:123871808-124454604 (-)



Homology
more
  • Human Ortholog
    ANK2, ankyrin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANK2, ankyrin 2
  • Synonyms
    ANK-2, brank-2, CFAP87, FAP87, LQT4
  • Links
    NCBI Gene ID: 287
    UniProt: Q01484

  • Chr Location
    4q25-q26; chr4:112705622-113384231 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with Ank2 mouse models; 4 with human ANK2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 2 models
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 6 alleles in 8 genetic backgrounds
    5 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032826 Ensembl Gene Model | MGI Sequence Detail 577739 C57BL/6J ±  kb
    transcript ENSMUST00000182064 Ensembl | MGI Sequence Detail 12413 Not Applicable  
    polypeptide ENSMUSP00000138620 Ensembl | MGI Sequence Detail 3926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      18 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR040745 Ankyrin, UPA domain
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR052391 E3 Ligase Complex Components and Neurotoxins
      IPR051165 Multifunctional Ankyrin Repeat Domain-Containing Protein
      IPR000906 ZU5 domain
    • GlyGen
      Q8C8R3 16 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (12 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 3
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1325, MGD-MRK-1328, MGI:2139799, MGI:2139987, MGI:3782577
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 22
      Diseases 4
      Gene Ontology 29
      Phenotypes 60
    • Earliest
      J:11441 Peters LL, et al., Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol. 1991 Sep;114(6):1233-41
    • Latest
      J:390068 Oldre EN, et al., Regulation of perisomatic synapses from cholecystokinin basket interneurons through NrCAM and Ankyrin B. Curr Res Neurobiol. 2025 Jun;8:100150

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory