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Ak4 Gene Detail
Summary
  • Symbol
    Ak4
  • Name
    adenylate kinase 4
  • Synonyms
    Ak-3, Ak3l1, Ak-4, D4Ertd274e
  • Feature Type
    protein coding gene
  • IDs
    MGI:87979
    NCBI Gene: 11639
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:101276474-101324192 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 46.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87979
 protein coding gene Chr4:101273675-101324968 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028492
 protein coding gene Chr4:101724083-101780932 (+)
A/J MGP_AJ_G0028455
 protein coding gene Chr4:98166418-98214705 (+)
AKR/J MGP_AKRJ_G0028402
 protein coding gene Chr4:100542223-100590306 (+)
BALB/cJ MGP_BALBcJ_G0028473
 protein coding gene Chr4:98368435-98434130 (+)
C3H/HeJ MGP_C3HHeJ_G0028186
 protein coding gene Chr4:101335272-101389661 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028912
 protein coding gene Chr4:105568530-105622706 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026204
 protein coding gene Chr4:93422458-93486587 (+)
CAST/EiJ MGP_CASTEiJ_G0027626
 protein coding gene Chr4:99124420-99176333 (+)
CBA/J MGP_CBAJ_G0028155
 protein coding gene Chr4:108885400-108942552 (+)
DBA/2J MGP_DBA2J_G0028305
 protein coding gene Chr4:97861653-97913468 (+)
FVB/NJ MGP_FVBNJ_G0028272
 protein coding gene Chr4:96701437-96750277 (+)
LP/J MGP_LPJ_G0028405
 protein coding gene Chr4:102022124-102084969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028300
 protein coding gene Chr4:114432442-114487805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028950
 protein coding gene Chr4:100791858-100843751 (+)
PWK/PhJ MGP_PWKPhJ_G0027351
 protein coding gene Chr4:96030251-96081176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027173
 protein coding gene Chr4:98242552-98299210 (+)
WSB/EiJ MGP_WSBEiJ_G0027704
 protein coding gene Chr4:100956358-101012327 (+)



Homology
more
  • Human Ortholog
    AK4, adenylate kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AK4, adenylate kinase 4
  • Synonyms
    AK3, AK3L1, AK3L2, AK 4
  • Links
    NCBI Gene ID: 205
    neXtProt AC: NX_P27144
    UniProt: P27144

  • Chr Location
    1p31.3; chr1:65147549-65232145 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    154
  • cDNA Data
    152
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028527 Ensembl Gene Model | MGI Sequence Detail 47719 C57BL/6J ±  kb
    transcript ENSMUST00000102780 Ensembl | MGI Sequence Detail 4186 Not Applicable  
    polypeptide ENSMUSP00000099841 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 1
      cDNA 154
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1242, MGD-MRK-1243, MGD-MRK-1246, MGD-MRK-1247, MGI:1098752, MGI:87980
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory