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Chrng Gene Detail
Summary
  • Symbol
    Chrng
  • Name
    cholinergic receptor, nicotinic, gamma polypeptide
  • Synonyms
    Achr-3, Acrg
  • Feature Type
    protein coding gene
  • IDs
    MGI:87895
    NCBI Gene: 11449
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87133533-87139365 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.07 cM
  • Mapping Data
    47 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    3
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87895
 protein coding gene Chr1:87132379-87140416 (+)
129S1/SvImJ ENSMUSG00200037260
 protein coding gene Chr1:84373063-84381093 (+)
A/J ENSMUSG00195028823
 protein coding gene Chr1:83933508-83941538 (+)
AKR/J ENSMUSG00220042202
 protein coding gene Chr1:84052028-84060065 (+)
BALB/cJ ENSMUSG00180014685
 protein coding gene Chr1:84221476-84229513 (+)
C3H/HeJ ENSMUSG00175001337
 protein coding gene Chr1:84107928-84115957 (+)
C57BL/6NJ ENSMUSG00215027982
 protein coding gene Chr1:84023369-84031406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014376
 protein coding gene Chr1:79682720-79690756 (+)
CAST/EiJ ENSTCUG00005006537
 protein coding gene Chr1:83665415-83673476 (+)
CBA/J ENSMUSG00210011755
 protein coding gene Chr1:83945748-83953787 (+)
DBA/2J ENSMUSG00185016459
 protein coding gene Chr1:88417861-88425890 (+)
FVB/NJ ENSMUSG00205027460
 protein coding gene Chr1:83367550-83375581 (+)
JF1/MsJ ENSUMUG00000013287
 protein coding gene Chr1:87173021-87181030 (+)
LP/J ENSMUSG00230019790
 protein coding gene Chr1:87702617-87710646 (+)
NOD/ShiLtJ ENSMUSG00190021922
 protein coding gene Chr1:84000990-84009027 (+)
NZO/HlLtJ ENSMUSG00225004354
 protein coding gene Chr1:91605328-91613357 (+)
PWK/PhJ ENSLUMG00010045039
 protein coding gene Chr1:83555326-83563371 (+)
SPRET/EiJ ENSMSPG00010041718
 protein coding gene Chr1:85571399-85578978 (+)
WSB/EiJ ENSIUOG00005038400
 protein coding gene Chr1:83596056-83604094 (+)



Homology
more
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
  • Synonyms
    ACHRG
  • Links
    NCBI Gene ID: 1146
    UniProt: P07510

  • Chr Location
    2q37.1; chr2:232539692-232548115 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHRNG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    64
  • cDNA Data
    27
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11449 NCBI Gene Model | MGI Sequence Detail 5833 C57BL/6J ±  kb
    transcript NM_009604 RefSeq | MGI Sequence Detail 1721 ZRU/MplStud  
    polypeptide P04760 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000005468 acetylcholine receptor subunit gamma
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      P04760 2 sites
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 7
      cDNA 30
      Primer pair 10
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1038, MGD-MRK-1070
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 22
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378747 Jing H, et al., Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance. J Neurosci. 2025 Aug 13;45(33)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory