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Acadm Gene Detail
Summary
  • Symbol
    Acadm
  • Name
    acyl-Coenzyme A dehydrogenase, medium chain
  • Synonyms
    MCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87867
    NCBI Gene: 11364
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:153627994-153650269 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 78.77 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    755 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87867
 protein coding gene Chr3:153627990-153650280 (-)
129S1/SvImJ ENSMUSG00200002399
 protein coding gene Chr3:150597548-150619605 (-)
A/J ENSMUSG00195003209
 protein coding gene Chr3:150714539-150736816 (-)
AKR/J ENSMUSG00220000217
 protein coding gene Chr3:149119277-149141325 (-)
BALB/cJ ENSMUSG00180026132
 protein coding gene Chr3:150566508-150588787 (-)
C3H/HeJ ENSMUSG00175018216
 protein coding gene Chr3:150183073-150205349 (-)
C57BL/6NJ ENSMUSG00215012869
 protein coding gene Chr3:150826478-150848754 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025752
 protein coding gene Chr3:146913060-146935566 (-)
CAST/EiJ ENSTCUG00005001068
 protein coding gene Chr3:151239383-151261371 (-)
CBA/J ENSMUSG00210004000
 protein coding gene Chr3:150823234-150845279 (-)
DBA/2J ENSMUSG00185024252
 protein coding gene Chr3:151452630-151474907 (-)
FVB/NJ ENSMUSG00205009204
 protein coding gene Chr3:149752552-149774605 (-)
JF1/MsJ ENSUMUG00000017304
 protein coding gene Chr3:150217625-150239512 (-)
LP/J ENSMUSG00230009416
 protein coding gene Chr3:153346614-153368667 (-)
NOD/ShiLtJ ENSMUSG00190004442
 protein coding gene Chr3:151806729-151829005 (-)
NZO/HlLtJ ENSMUSG00225004836
 protein coding gene Chr3:155847296-155869572 (-)
PWK/PhJ ENSLUMG00010001738
 protein coding gene Chr3:150144085-150166083 (-)
SPRET/EiJ ENSMSPG00010008058
 protein coding gene Chr3:151468334-151490876 (-)
WSB/EiJ ENSIUOG00005015164
 protein coding gene Chr3:150917484-150939783 (-)



Homology
more
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase medium chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase medium chain
  • Synonyms
    ACAD1, MCAD, MCADH
  • Links
    NCBI Gene ID: 34
    UniProt: P11310

  • Chr Location
    1p31.1; chr1:75724431-75787575 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acadm mouse models; 1 with human ACADM associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    231
  • cDNA Data
    302
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062908 Ensembl Gene Model | MGI Sequence Detail 22276 C57BL/6J ±  kb
    transcript ENSMUST00000072697 Ensembl | MGI Sequence Detail 2047 Not Applicable  
    polypeptide ENSMUSP00000072483 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003601 medium-chain specific acyl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.7
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR006091 Acyl-CoA dehydrogenase/oxidase, middle domain
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR034180 Medium-chain specific acyl-CoA dehydrogenase
    • GlyGen
      P45952 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 318
      Genomic 3
      cDNA 307
      Primer pair 7
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1024, MGI:2139874
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 15
      Phenotypes 18
    • Earliest
      J:14629 Kelly DP, et al., Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72
    • Latest
      J:362260 Maruyama T, et al., Medium-chain triglyceride-specific appetite is regulated by the beta-oxidation of medium-chain fatty acids in the liver. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E735-E746
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory