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Gene Expression Data
Assay Details
Assay
Reference: J:344365 Abad C, et al., Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning. Transl Psychiatry. 2024 Jan 18;14(1):33
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8400449
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Antibody: anti-CTIP2 [25B6] (ab18465)
Detection system: Secondary antibody
Results
Specimen 4A WT: embryonic day 16.5 (more )
Note: Double labeled: red - Bcl11b; green - Satb2 (assay MGI:8400448).
Structure Level Pattern Image Note
TS24: cerebral cortex Present 4A WT Ctip2 , 4A WT Merge
Specimen 4A stop/+: embryonic day 16.5; Gatad2btm1a(EUCOMM)Hmgu/Gatad2b+ (more )
Note: Double labeled: red - Bcl11b; green - Satb2 (assay MGI:8400448).
Structure Level Pattern Image Note
TS24: cerebral cortex Present Regionally restricted 4A stop/+ Ctip2 , 4A stop/+ Merge Significantly higher number of cells co-expressing Satb2 and Bcl11b compared to controls.
Specimen 4B +/+: embryonic day 16.5 (more )
Note: Triple labeled: red - Bcl11b; green - Satb2 (assay MGI:8400448); blue - Tbr1 (assay MGI:8400450).
Structure Level Pattern Image Note
TS24: cerebral cortex Present 4B +/+
Specimen 4B stop/+: embryonic day 16.5; Gatad2btm1a(EUCOMM)Hmgu/Gatad2b+ (more )
Note: Triple labeled: red - Bcl11b; green - Satb2 (assay MGI:8400448); blue - Tbr1 (assay MGI:8400450).
Structure Level Pattern Image Note
TS24: cerebral cortex Present Regionally restricted 4B stop/+ Proportion of expressing cells vo-expressing Tbr1 in layer V significantly higher compared to wild type.
Specimen 4B stop/stop: embryonic day 16.5; Gatad2btm1a(EUCOMM)Hmgu/Gatad2btm1a(EUCOMM)Hmgu (more )
Note: Triple labeled: red - Bcl11b; green - Satb2 (assay MGI:8400448); blue - Tbr1 (assay MGI:8400450).
Structure Level Pattern Image Note
TS24: cerebral cortex Present Regionally restricted 4B stop/stop Proportion of expressing cells vo-expressing Tbr1 in layer V significantly higher compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory