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Gene Expression Data
Assay Details
Assay
Reference: J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7856698
Gene symbol: Ccnd1
Gene name: cyclin D1
Antibody: anticyclin (CYC) D1 (72-13G, SC-450)
Detection system: Secondary antibody
Results
Specimen 1g Control: embryonic day 12.5 (more )
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.
Structure Level Pattern Image Note
TS20: cerebral cortex Present 1g Control
Specimen 1g Yy1cKO: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebral cortex Weak 1g Yy1cKO Decreased percentage of expressing cells compared to control.
Specimen 1h Control: embryonic day 15.5 (more )
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.
Structure Level Pattern Image Note
TS23: cerebral cortex Present 1h Control
Specimen 1h Yy1cKO: embryonic day 15.5; Emx1tm1(cre)Krj/Emx1+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: cerebral cortex Present 1h Yy1cKO Percentage of expressing cells not decreased compared to control.
Specimen 3j Control Trp53: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn, Yy1tm2.1Yshi/Yy1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebral cortex Present 3j Control Trp53
Specimen 3j Yy1Trp53dKO: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebral cortex Weak 3j Yy1Trp53dKO Authors report decrease in number of expressing cells was not rescued.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory