Casp3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7856693
Gene symbol:	Casp3
Gene name:	caspase 3

Antibody:	anti-cleaved Caspase-3 (Asp175; #9661)
Detection system:	Secondary antibody

Results

S1l Control ©

S1l Control inset ©

Specimen S1l Control: embryonic day 10.5 (more

)
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.

Structure	Level	Pattern	Image	Note
TS17: telencephalon	Ambiguous		S1l Control , S1l Control inset

S1l Yy1cKO ©

S1l Yy1cKO inset ©

Specimen S1l Yy1cKO: embryonic day 10.5; Emx1^tm1(cre)Krj/Emx1⁺, Yy1^tm2.1Yshi/Yy1^tm2.1Yshi (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS17: telencephalon	Ambiguous		S1l Yy1cKO , S1l Yy1cKO inset

S1m Control ©

S1m Control inset ©

Specimen S1m Control: embryonic day 11.5 (more

)
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.

Structure	Level	Pattern	Image	Note
TS19: telencephalon	Ambiguous		S1m Control inset , S1m Control

S1m Yy1cKO ©

S1m Yy1cKO inset ©

Specimen S1m Yy1cKO: embryonic day 11.5; Emx1^tm1(cre)Krj/Emx1⁺, Yy1^tm2.1Yshi/Yy1^tm2.1Yshi (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: telencephalon	Trace		S1m Yy1cKO , S1m Yy1cKO inset	Number of expressing cells starts to increase but is not statistically significant at E11.5.

1m Control ©

1m Control inset ©

Specimen 1m Control: embryonic day 12.5 (more

)
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.

Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Ambiguous		1m Control , 1m Control inset

1m Yy1cKO ©

1m Yy1cKO inset ©

Specimen 1m Yy1cKO: embryonic day 12.5; Emx1^tm1(cre)Krj/Emx1⁺, Yy1^tm2.1Yshi/Yy1^tm2.1Yshi (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Present		1m Yy1cKO , 1m Yy1cKO inset	Number of expressing cells transiently increases at E12.5

1n Control ©

1n Control inset ©

Specimen 1n Control: embryonic day 15.5 (more

)
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex	Ambiguous		1n Control , 1n Control inset

1n Yy1cKO ©

Specimen 1n Yy1cKO: embryonic day 15.5; Emx1^tm1(cre)Krj/Emx1⁺, Yy1^tm2.1Yshi/Yy1^tm2.1Yshi (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex	Trace		1n Yy1cKO , 1n Yy1cKO inset

Specimen 3f Control Trp53: embryonic day 12.5; Emx1^tm1(cre)Krj/Emx1⁺, Trp53^tm1Brn/Trp53^tm1Brn, Yy1^tm2.1Yshi/Yy1⁺ (more

)
Note: Conditional mutant. The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt.

Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Ambiguous		3f Control Trp53 , 3f Control Trp53 inset

Specimen 3f Yy1Trp53dKO: embryonic day 12.5; Emx1^tm1(cre)Krj/Emx1⁺, Trp53^tm1Brn/Trp53^tm1Brn, Yy1^tm2.1Yshi/Yy1^tm2.1Yshi (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: cerebral cortex	Absent		3f Yy1Trp53dKO , 3f Yy1Trp53dKO inset	Emergence of expression completely abolished.

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