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Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788465
Gene symbol: Glul
Gene name: glutamate-ammonia ligase
Results
Specimen 2E WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present 2E WT
Specimen 2E cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present 2E cKO A 50% reduction was seen.
Specimen 2J WT: postnatal day 120 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present 2J WT
Specimen 2J cKO: postnatal day 120; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present Scattered 2J cKO All layers were further reduced in thickness, with sparsely populated and disorganized Mueller cells.
Specimen 3E/G/H WT: postnatal day 21 (more )
Note: Double labeled: green - Glul; red - Mapk1 (assay MGI:7788479) and Mapk3 (assay MGI:7789050).
Structure Cell Type Level Pattern Image Note
TS28: retina inner nuclear layer Mueller cell Present 3E WT , 3H WT , 3G WT
TS28: retina layer Mueller cell Present 3E WT
Specimen 3E/G/H cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Double labeled: green - Glul; red - Mapk1 (assay MGI:7788479) and Mapk3 (assay MGI:7789050).
Structure Cell Type Level Pattern Image Note
TS28: retina inner nuclear layer Mueller cell Present 3G cKO , 3H cKO , 3E cKO
TS28: retina layer Mueller cell Present 3E cKO
Specimen S3I: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present S3I
Specimen S3J: postnatal day 7; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present S3J Similar as in the wild-type.
Specimen not shown: postnatal day 21; Krastm4Tyj/Krastm4Tyj, Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Quantified in Fig 6T.
Structure Cell Type Level Pattern Image Note
TS28: retina layer Mueller cell Present Expression was restored to the wild-type level.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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