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Gene Expression Data
Assay Details
Assay
Reference: J:316648 Suflita MT, et al., Ground-state transcriptional requirements for skin-derived precursors. Stem Cells Dev. 2013 Jun 15;22(12):1779-88
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7785107
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Results
Specimen 1B: embryonic day 8.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant. Double labeled: magenta - Sox2; green - Rosa-YFP.
Structure Cell Type Level Pattern Image Note
TS13: neural crest neural crest cell Present Regionally restricted 1B Expression was detected in premigratory and migratory cranial neural crest cells.
TS13: migrating neural crest migratory neural crest cell Present Regionally restricted 1B Expression was detected in migratory cranial neural crest cells.

Specimen 1D: embryonic day 9.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant. Double labeled: magenta - Sox2; green - Rosa-YFP.
Structure Cell Type Level Pattern Image Note
TS15: migrating neural crest migratory neural crest cell Weak Regionally restricted 1D , 1E Low level expression was detected in trunk neural crest cells as they emigrate from the neural tube.

Specimen 1F: embryonic day 12.5 (more )
Note: Double labeled: magenta - Sox2; green - Foxd3 (assay MGI:7785117).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 1F At 12.5 dpc Foxd3 and Sox2 are co-expressed in the dorsal root ganglion.

Specimen 2A: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant. Triple labeled: red - Sox2; blue - Foxd3 (assay MGI:7785117); green - Rosa-YFP.
Structure Level Pattern Image Note
TS21: vibrissa dermal component Present 2C , 2A , 2B At 12.5 dpc, expression was detected in the dermal condensates. Co-expression with Foxd3 was observed.

Specimen 2E: embryonic day 17.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant. Triple labeled: red - Sox2; blue - Foxd3 (assay MGI:7785117); green - Rosa-YFP.
Structure Level Pattern Image Note
TS25: vibrissa dermal papilla Present 2E , 2G , 2F Expression was detected in the neural crest lineage in the dermal papilla. Co-expression with Foxd3 was observed.
TS25: vibrissa follicle Present Regionally restricted 2E , 2G , 2F Expression was detected in the non-neural crest lineage in the more proximal part of the whisker follicle. This expression domain did not co-label with Foxd3.

Specimen 4C: embryonic day 16.5; Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: dorsal root ganglion Present 4C

Specimen 4D: embryonic day 16.5; Sox2tm2Lpev/Sox2tm2Lpev, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: dorsal root ganglion Absent 4D

Specimen 5A: embryonic day 17.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant. Triple labeled: red - Sox2; blue - Foxd3 (assay MGI:7785117); green - Rosa-YFP.
Structure Level Pattern Image Note
TS25: vibrissa follicle Present Regionally restricted 5C , 5A , 5B Expression was detected in the neural crest lineage domain, where it overlapped with Foxd3, and in a domain outside the neural crest lineage.

Specimen 5E: embryonic day 17.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Sox2tm2Lpev/Sox2tm2Lpev, Tg(Wnt1-cre/Esr1*)10Rth/0 (more )
Note: Conditional mutant. Triple labeled: red - Sox2; blue - Foxd3 (assay MGI:7785117); green - Rosa-YFP.
Structure Level Pattern Image Note
TS25: vibrissa follicle Present Regionally restricted 5E , 5G , 5F Expression was lost in the neural crest lineage in the mutant. The non-neural crest lineage expression was unchanged in the mutant.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory