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Gene Expression Data
Assay Details
Assay
Reference: J:198779 Nitzan E, et al., Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12709-14
Assay type: RNA in situ
MGI Accession ID: MGI:7780008
Gene symbol: Erbb3
Gene name: erb-b2 receptor tyrosine kinase 3
Probe: ErbB3 probe1
Probe preparation: Antisense RNA
Results
Specimen S3A: embryonic day 11.5; Foxd3+/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: dorsal root ganglion Present S3A
TS19: skeletal musculature Present S3A
TS19: spinal nerve Schwann cell precursor Strong S3A
Specimen S3B: embryonic day 11.5; Foxd3tm1Lby/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: dorsal root ganglion Present S3B Reduced expression and mainly localized to cells in the ganglion periphery in the mutant. Overall DRG size was slightly reduced in mutants.
TS19: spinal nerve Schwann cell precursor Strong S3B No apparent change in the pattern, compared with the control.
TS19: skeletal musculature Present S3B
Specimen S3C/C': embryonic day 12.5; Foxd3+/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal nerve Schwann cell precursor Strong S3C
TS20: dorsal root ganglion Present S3C' , S3C
TS20: skeletal muscle Present S3C' , S3C
Specimen S3D/D': embryonic day 12.5; Foxd3tm1Lby/Foxd3tm3Lby, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal nerve Schwann cell precursor Strong S3D No apparent change in the pattern, compared with the control.
TS20: dorsal root ganglion Present S3D' , S3D Reduced expression and mainly localized to cells in the ganglion periphery in the mutant. Overall DRG size was slightly reduced in mutants.
TS20: skeletal muscle Present S3D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory