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Gene Expression Data
Assay Details
Assay
Reference: J:279388 Weiss AC, et al., Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7718875
Gene symbol: Upk1b
Gene name: uroplakin 1B
Antibody: Anti-Upk1b
Results
Specimen 2A': embryonic day 18.5; Gata2tm1Sac/? (more )
Note: Littermates without the Tbx18cre were used as control.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter intermediate cell of urothelium Present 2A' Expression of KRT5, deltaNP63, and UPK1B combinatorially mark basal cells (KRT5+deltaNP63+UPK1B-), intermediate cells (KRT5-deltaNP63+UPK1B+), and superficial cells (KRT5-deltaNP63-UPK1B+) in the urothelium.
TS26: urothelium of ureter umbrella cell of urothelium Present 2A' Expression of KRT5, deltaNP63, and UPK1B combinatorially mark basal cells (KRT5+deltaNP63+UPK1B-), intermediate cells (KRT5-deltaNP63+UPK1B+), and superficial cells (KRT5-deltaNP63-UPK1B+) in the urothelium.
TS26: urothelium of ureter basal cell of urothelium Absent 2A' Expression of KRT5, deltaNP63, and UPK1B combinatorially mark basal cells (KRT5+deltaNP63+UPK1B-), intermediate cells (KRT5-deltaNP63+UPK1B+), and superficial cells (KRT5-deltaNP63-UPK1B+) in the urothelium.
Specimen 2B': embryonic day 18.5; Gata2tm1Sac/Gata2tm1Sac, Tbx18tm4(cre)Akis/Tbx18+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter intermediate cell of urothelium Present 2B' Expression was not affected in Gata2cKO.
TS26: urothelium of ureter umbrella cell of urothelium Present 2B' Expression was not affected in Gata2cKO.
TS26: urothelium of ureter basal cell of urothelium Absent 2B' Expression was not affected in Gata2cKO.
Specimen S4O: embryonic day 18.5; Gata2tm1Sac/? (more )
Note: Littermates without the Tbx18cre were used as control.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter intermediate cell of urothelium Present S4O Expression of KRT5, deltaNP63, and UPK1B combinatorially mark basal cells (KRT5+deltaNP63+UPK1B-), intermediate cells (KRT5-deltaNP63+UPK1B+), and superficial cells (KRT5-deltaNP63-UPK1B+) in the urothelium.
TS26: urothelium of ureter umbrella cell of urothelium Present S4O Expression of KRT5, deltaNP63, and UPK1B combinatorially mark basal cells (KRT5+deltaNP63+UPK1B-), intermediate cells (KRT5-deltaNP63+UPK1B+), and superficial cells (KRT5-deltaNP63-UPK1B+) in the urothelium.
TS26: urothelium of ureter basal cell of urothelium Absent S4O Expression of KRT5, deltaNP63, and UPK1B combinatorially mark basal cells (KRT5+deltaNP63+UPK1B-), intermediate cells (KRT5-deltaNP63+UPK1B+), and superficial cells (KRT5-deltaNP63-UPK1B+) in the urothelium.
Specimen S4P: embryonic day 18.5; Gata2tm1Sac/Gata2tm1Sac, Tbx18tm4(cre)Akis/Tbx18+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter intermediate cell of urothelium Present S4P Expression was not affected in Gata2cKO.
TS26: urothelium of ureter umbrella cell of urothelium Present S4P Expression was not affected in Gata2cKO.
TS26: urothelium of ureter basal cell of urothelium Absent S4P Expression was not affected in Gata2cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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