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Gene Expression Data
Assay Details
Assay
Reference: J:154534 Martinez G, et al., Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7660521
Gene symbol: Ccnd1
Gene name: cyclin D1
Antibody: Anti-Cyclin D1 [SP4] ab21699
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8E: embryonic day 13.5 (more )
Note: Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Present 8E
TS21: lens Strong Regionally restricted 8E Expression was detected in epithelial and equatorial cells. Strong expression was detected in cells of the germinative and early transitional zones with expression decreasing as cells undergo terminal differentiation.
Specimen 8F: embryonic day 13.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(Cryaa-cre,Tyr)39Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Present 8F
TS21: lens Present Regionally restricted 8F Expression was detected in epithelial and equatorial cells. Strong expression was detected in cells of the germinative and early transitional zones with expression decreasing as cells undergo terminal differentiation.
Specimen 8G: embryonic day 13.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Level Pattern Image Note
TS21: lens fiber Present Widespread 8G Pronounced immunoreactivity was detected throughout the fiber compartment.
Specimen 8H: embryonic day 13.5; Apctm1Tno/Apctm1Tno, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Level Pattern Image Note
TS21: lens fiber Present Widespread 8H Pronounced immunoreactivity was detected throughout the fiber compartment.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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