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Gene Expression Data
Assay Details
Assay
Reference: J:160964 Li J, et al., Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8916-21
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7628747
Gene symbol: Acta2
Gene name: actin alpha 2, smooth muscle, aorta
Results
Specimen 4E: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: 3rd arch artery blood vessel smooth muscle cell Strong 4E
TS19: 4th arch artery blood vessel smooth muscle cell Strong 4E
TS19: 6th arch artery blood vessel smooth muscle cell Strong 4E
Specimen 4G: embryonic day 11.5; MrtfbGt(RRJ478)Byg/MrtfbGt(RRJ478)Byg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: 3rd arch artery blood vessel smooth muscle cell Present 4G Markedly down-regulated expression compared with the wild-type.
TS19: 4th arch artery blood vessel smooth muscle cell Weak 4G Barely detectable expression.
TS19: 6th arch artery blood vessel smooth muscle cell Weak 4G Barely detectable expression.
TS19: aortic sac blood vessel smooth muscle cell Present 4G Dilated aortic sac.
TS19: branchial arch mesenchyme blood vessel smooth muscle cell Present 4G Severely dilated aortic arch arteries, absent arch arteries were seen.
Specimen 4I: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: aortico-pulmonary spiral septum Present Regionally restricted 4I Expressed in the cells forming the nascent septum that divides the truncus arteriosus into the aorta and pulmonary artery.
Specimen 4K: embryonic day 11.5; MrtfbGt(RRJ478)Byg/MrtfbGt(RRJ478)Byg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: outflow tract Trace Regionally restricted 4K The aorticopulmonary septum failed to develop, either absent or severely diminished. Positive cells were rarely observed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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