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Gene Expression Data
Assay Details
Assay
Reference: J:302618 Wang B, et al., The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy. 2018;14(5):796-811
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7616440
Gene symbol: Chl1
Gene name: cell adhesion molecule L1-like
Antibody: Anti-Neural Cell Adhesion Molecule L1, clone 324 (MAB5272)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 6E E18.5 Control: embryonic day 18.5 (more )
Note: Double labeled: red - Chl1; green - Gfap (assay MGI:7616441).
Structure Level Pattern Image Note
TS26: corpus callosum Present 6E E18.5 control
Specimen 6E E18.5 DKO: embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Double labeled: red - Chl1; green - Gfap (assay MGI:7616441).
Structure Level Pattern Image Note
TS26: corpus callosum Present 6E E18.5 DKO The corpus callosum was thinner compared to that in littermate controls.
Specimen 6E P0 Control: postnatal day 0 (more )
Note: Double labeled: red - Chl1; green - Gfap (assay MGI:7616441).
Structure Level Pattern Image Note
TS27: corpus callosum Present 6E P0 control
Specimen 6E P0 Ulk1/2-cDKO: postnatal day 0; Tg(Nes-cre)1Kln/0, Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1Thsn (more )
Note: Conditional mutant. Double labeled: red - Chl1; green - Gfap (assay MGI:7616441).
Structure Level Pattern Image Note
TS27: corpus callosum Present 6E P0 cDKO Dysgenesis was seen.
Specimen 6F E15.5 Control: embryonic day 15.5 (more )
Note: Double labeled: red - Chl1; green - Calr (assay MGI:7616442).
Structure Level Pattern Image Note
TS23: allocortex Present 6F E15.5 control
Specimen 6F E15.5 DKO: embryonic day 15.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Double labeled: red - Chl1; green - Calr (assay MGI:7616442).
Structure Level Pattern Image Note
TS23: allocortex Present 6F E15.5 DKO
Specimen 6F E18.5 Control: embryonic day 18.5 (more )
Note: Double labeled: red - Chl1; green - Calr (assay MGI:7616442).
Structure Level Pattern Image Note
TS26: corpus callosum Present 6F E18.5 control
Specimen 6F E18.5 DKO: embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Double labeled: red - Chl1; green - Calr (assay MGI:7616442).
Structure Level Pattern Image Note
TS26: corpus callosum Present 6F E18.5 DKO The corpus callosum was thinner compared to that in littermate controls.
Specimen S1C Control: embryonic day 18.5 (more )
Note: Double labeled: red - Chl1; green - Nefm (assay MGI:7616450).
Structure Level Pattern Image Note
TS26: forebrain Present S1C control
Specimen S1C DKO: embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Double labeled: red - Chl1; green - Nefm (assay MGI:7616450).
Structure Level Pattern Image Note
TS26: forebrain Present Regionally restricted S1C DKO Mutant corticothalamic and thalamocortical axons were disorganized, overfasciculated, and traversed the pallial-subpallial boundary more anteroventrally than axons in littermate controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory