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Gene Expression Data
Assay Details
Assay
Reference: J:308818 Moreau MX, et al., Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Development. 2021 Jul 15;148(14):dev197962
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7606763
Gene symbol: Nfib
Gene name: nuclear factor I/B
Results
Specimen 4A top: embryonic day 12.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Wnt3atm1(cre)Eag/Wnt3a+ (more )
Note: Conditional mutant. Double labeled: green - Nfib; red - Rosa26tdTomato.
Structure Cell Type Level Pattern Image Note
TS20: telencephalon Cajal-Retzius cell Present Regionally restricted 4A top left , 4A top right Merge , 4A top right Nfib All tomato-positive (hem-derived Cajal-Retzius) cells also express Nfib.
Specimen 4A bottom: embryonic day 12.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Wnt3atm1(cre)Eag/Wnt3a+ (more )
Note: Conditional mutant. Double labeled: green - Nfib; red - Rosa26tdTomato.
Structure Cell Type Level Pattern Image Note
TS20: telencephalon Cajal-Retzius cell Present Regionally restricted 4A bottom right b Merge , 4A bottom right a Merge , 4A bottom right a Nfib , 4A bottom left , 4A bottom right b Nfib All tomato-positive (hem-derived Cajal-Retzius) cells also express Nfib.
Specimen 4B top: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Trp73tm1(cre)Agof/Trp73+ (more )
Note: Conditional mutant. Double labeled: red - Nfib; green - Rosa26YFP.
Structure Cell Type Level Pattern Image Note
TS20: telencephalon Cajal-Retzius cell Present Regionally restricted 4B top left , 4B top right Merge , 4B top right Nfib The deltaNp73Cre line, which labels Cajal-Retzius cells from the hem, septum and thalamic eminence, allowed the identification of some Nfib-negative Cajal-Retzius cells at all mediolateral levels.
Specimen 4B bottom: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Trp73tm1(cre)Agof/Trp73+ (more )
Note: Conditional mutant. Double labeled: red - Nfib; green - Rosa26YFP.
Structure Cell Type Level Pattern Image Note
TS20: telencephalon Cajal-Retzius cell Present Regionally restricted 4B bottom right b Nfib , 4B bottom right a Merge , 4B bottom left , 4B bottom right a Nfib , 4B bottom right b Merge The deltaNp73Cre line, which labels Cajal-Retzius cells from the hem, septum and thalamic eminence, allowed the identification of some Nfib-negative Cajal-Retzius cells at all mediolateral levels.
Specimen 4D top: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: red - Nfib; blue - Bhlhe22 (assay MGI:7606796); green - Rosa26YFP.
Structure Level Pattern Image Note
TS20: pallium Present Regionally restricted 4D top right Nfib , 4D top right Merge , 4D top left Emx1Cre recombines mostly in lateral and dorsal pallium progenitors; 96% of Nfib+ and 93% of Bhlhe22+ cells were from the Emx1 lineage.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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